HitPredict

Interactor 1: MP2K1 (Q02750)
Dual specificity mitogen-activated protein kinase kinase 1 (MAP kinase kinase 1) (MAPKK 1) (MKK1) (EC 2.7.12.2) (ERK activator kinase 1) (MAPK/ERK kinase 1) (MEK 1)
Gene: MAP2K1

Interactor 2: HNRPD (Q14103)
Heterogeneous nuclear ribonucleoprotein D0 (hnRNP D0) (AU-rich element RNA-binding protein 1)
Gene: HNRNPD

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	15231747
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Pkinase~RRM_1
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0045893 - positive regulation of DNA-templated transcription
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 393 Hs			1 355
+	Hs
		625424 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		HNRPD_HUMAN (1-355): 9.1e-72: 229: 100.00
+	Hs
		162017 MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00		HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63
+	Hs
		161966 MARK3_HUMAN (1-352): 4.84e-120: 366: 19.72		HNRDL_HUMAN (89-355): 3.71e-56: 190: 62.63
+	Sc
		691147 HOG1_YEAST (66-393): 1.71e-122: 362: 21.15		HRP1_YEAST (16-327): 5.93e-51: 179: 31.31
+	Dm
		995767 AKT1_DROME (45-389): 1.44e-121: 366: 19.49		SQD_DROME (78-264): 4.23e-42: 151: 42.55
+	Hs
		516362 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		PABP1_HUMAN (88-272): 2.1e-42: 157: 16.93
+	Rn
		1144336 AKT3_RAT (20-377): 9.53e-112: 337: 21.43		PABP1_RAT (88-272): 2.23e-42: 157: 16.93
+	Hs
		516486 STK4_HUMAN (37-369): 2.53e-111: 336: 30.06		PABP1_HUMAN (88-272): 2.1e-42: 157: 16.93
+	Dm
		995759 DSOR1_DROME (12-392): 4.19e-114: 340: 61.42		SQD_DROME (78-264): 4.23e-42: 151: 42.55
+	Hs
		852214 STK24_HUMAN (65-364): 1.58e-102: 312: 32.12		ROA3_HUMAN (64-265): 2.66e-50: 174: 37.02
+	Hs
		453300 MP2K1_HUMAN (1-393): 1.26e-125: 369: 100.00		ROA1_HUMAN (63-177): 4.79e-20: 92: 26.83
+	Hs
		453153 CDK2_HUMAN (65-367): 2.85e-123: 359: 24.27		ROA1_HUMAN (63-177): 4.79e-20: 92: 26.83
+	Dm
		1213421 AKT1_DROME (45-389): 1.44e-121: 366: 19.49		MSIR6_DROME (21-180): 5.08e-17: 83.3: 32.10
+	Mm
		682461 MP2K1_MOUSE (1-393): 9.74e-125: 367: 98.98		TIA1_MOUSE (176-270): 8.88e-14: 73.6: 18.75
+	Hs
		415020 CDK1_HUMAN (65-367): 7.64e-110: 325: 26.45		MSI2H_HUMAN (21-198): 1.49e-15: 78.3: 26.82
+	Sc
		420038 STE7_YEAST (67-374): 1.43e-65: 218: 37.58		HRP1_YEAST (16-327): 5.93e-51: 179: 31.31
+	Sc
		691248 MKK2_YEAST (46-361): 4.02e-55: 191: 37.50		HRP1_YEAST (16-327): 5.93e-51: 179: 31.31