HitPredict

Interactor 1: M3K10 (Q02779)
Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)
Gene: MAP3K10

Interactor 2: 1433F (Q04917)
14-3-3 protein eta (Protein AS1)
Gene: YWHAH

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36931259
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 954 Hs			1 246
+	Hs
		909462 M3K10_HUMAN (1-954): 0: 726: 100.00		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		904461 M3K10_HUMAN (1-954): 0: 726: 100.00		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		926946 M3K10_HUMAN (1-954): 0: 726: 100.00		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683281 M3K10_HUMAN (1-954): 0: 726: 100.00		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		646816 M3K10_HUMAN (1-954): 0: 726: 100.00		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		683977 M3K10_HUMAN (1-954): 0: 726: 100.00		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20
+	Hs
		909438 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		904440 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		945770 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Hs
		909655 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433E_HUMAN (1-244): 1.37e-141: 398: 62.71
+	Hs
		904685 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433G_HUMAN (1-246): 9.38e-138: 388: 86.99
+	Hs
		982110 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433F_HUMAN (1-246): 6.09e-136: 383: 100.00
+	Hs
		926918 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683262 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		646793 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		927141 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433Z_HUMAN (3-245): 1.27e-107: 312: 74.49
+	Hs
		683421 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433B_HUMAN (3-245): 2.7e-107: 311: 75.51
+	Hs
		683959 M3K9_HUMAN (11-951): 5.29e-179: 550: 50.77		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20
+	Hs
		646976 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433T_HUMAN (3-245): 7.19e-106: 307: 71.43
+	Hs
		684098 M3K21_HUMAN (20-952): 3.06e-170: 525: 45.59		1433S_HUMAN (3-245): 2.76e-96: 283: 64.20