Protein: YTDC2
3'-5' RNA helicase YTHDC2 (EC 3.6.4.13) (YTH domain-containing protein 2) (hYTHDC2)

Gene: YTDC2, YTHDC2
Organism: Homo sapiens
Interactions: 227
UniProt ID: Q9H6S0

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004386 - helicase activity
GO:0005524 - ATP binding
GO:0005783 - endoplasmic reticulum
GO:0007286 - spermatid development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346332

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

20

High-throughput

0.827

High

182368

WDR46
WD repeat-containing protein 46

2

14

High-throughput

0.789

High

975943

RL7A
Large ribosomal subunit protein eL8

2

4

High-throughput

0.776

High

287136

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

20

High-throughput

0.691

High

301209

RL1D1
Ribosomal L1 domain-containing protein 1

1

5

High-throughput

0.691

High

985339

RL10A
Large ribosomal subunit protein uL1

1

7

High-throughput

0.691

High

1008888

RED1
Double-stranded RNA-specific editase 1

1

19

High-throughput

0.691

High

1027758

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

11

High-throughput

0.691

High

1089869

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.691

High

1435114

DDX21
Nucleolar RNA helicase 2

1

16

High-throughput

0.691

High

1435135

RL36
Large ribosomal subunit protein eL36

1

4

High-throughput

0.691

High

903253

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

13

High-throughput

0.665

High

1194381

LARP7
La-related protein 7

3

20

High-throughput

0.650

High

1009321

PRR3
Proline-rich protein 3

3

4

High-throughput

0.643

High

1435109

LN28A
Protein lin-28 homolog A

3

18

High-throughput

0.643

High

970108

RS16
Small ribosomal subunit protein uS9

2

8

High-throughput

0.628

High

972566

RS14
Small ribosomal subunit protein uS11

2

3

High-throughput

0.628

High

1037646

RL18A
Large ribosomal subunit protein eL20

2

2

High-throughput

0.628

High

1151197

OASL
2'-5'-oligoadenylate synthase-like protein

2

10

High-throughput

0.628

High

1429097

NXF2
Nuclear RNA export factor 2

2

2

High-throughput

0.628

High

1435119

NOP53
Ribosome biogenesis protein NOP53

2

2

High-throughput

0.628

High

1006713

SRPK2
SRSF protein kinase 2

2

19

High-throughput

0.619

High

905680

IRAK1
Interleukin-1 receptor-associated kinase 1

2

0

High-throughput

0.618

High

1092244

NFX1
Transcriptional repressor NF-X1

1

10

High-throughput

0.618

High

1370377

CSN5
COP9 signalosome complex subunit 5

2

11

High-throughput

0.611

High

1332715

ZBT38
Zinc finger and BTB domain-containing protein 38

3

5

High-throughput

0.609

High

1276065

ZN550
Zinc finger protein 550

3

2

High-throughput

0.604

High

290734

SURF6
Surfeit locus protein 6

2

4

High-throughput

0.601

High

658408

RS3
Small ribosomal subunit protein uS3

2

4

High-throughput

0.601

High

809847

RS19
Small ribosomal subunit protein eS19

2

4

High-throughput

0.601

High

824361

RL13A
Large ribosomal subunit protein uL13

2

2

High-throughput

0.601

High

860949

RS10
Small ribosomal subunit protein eS10

2

6

High-throughput

0.601

High

1016230

RL19
Large ribosomal subunit protein eL19

2

5

High-throughput

0.601

High

1231663

RL7L
Ribosomal protein uL30-like

2

2

High-throughput

0.601

High

1435122

PURG
Purine-rich element-binding protein gamma

2

4

High-throughput

0.601

High

1435124

ZN346
Zinc finger protein 346

2

8

High-throughput

0.601

High

1435126

ABT1
Activator of basal transcription 1

2

4

High-throughput

0.601

High

1435134

YBOX2
Y-box-binding protein 2

2

16

High-throughput

0.601

High

1360821

ASB11
Ankyrin repeat and SOCS box protein 11

1

0

High-throughput

0.586

High

242934

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.584

High

644059

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

5

High-throughput

0.584

High

1435131

DICER
Endoribonuclease Dicer

1

16

Small-scale

0.575

High

546999

FGF3
Fibroblast growth factor 3

2

12

High-throughput

0.574

High

935451

FGF8
Fibroblast growth factor 8

2

12

High-throughput

0.574

High

1230903

Z324B
Zinc finger protein 324B

2

2

High-throughput

0.574

High

1397713

ZSC31
Zinc finger and SCAN domain-containing protein 31

2

4

High-throughput

0.574

High

1398074

ZN512
Zinc finger protein 512

2

1

High-throughput

0.574

High

810380

RL3
Large ribosomal subunit protein uL3

2

5

High-throughput

0.571

High

1114306

CUL3
Cullin-3

2

20

High-throughput

0.558

High

1106072

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

6

High-throughput

0.553

High

1227466

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.553

High

1255552

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.553

High

1435123

FBW1B
F-box/WD repeat-containing protein 11

1

13

High-throughput

0.553

High

1435125

HECD1
E3 ubiquitin-protein ligase HECTD1

1

18

High-throughput

0.553

High

191803

MAGB2
Melanoma-associated antigen B2

2

8

High-throughput

0.549

High

336206

TNF6B
Tumor necrosis factor receptor superfamily member 6B

2

2

High-throughput

0.549

High

338964

CBX6
Chromobox protein homolog 6

2

9

High-throughput

0.549

High

74605

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

12

High-throughput

0.536

High

208381

RRP8
Ribosomal RNA-processing protein 8

1

1

High-throughput

0.536

High

250832

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

6

High-throughput

0.536

High

428984

RLA0
Large ribosomal subunit protein uL10

1

6

High-throughput

0.536

High

521938

H14
Histone H1.4

1

20

High-throughput

0.536

High

549023

KPSH1
Serine/threonine-protein kinase H1

1

1

High-throughput

0.536

High

595595

H15
Histone H1.5

1

20

High-throughput

0.536

High

596355

H12
Histone H1.2

1

20

High-throughput

0.536

High

615986

RL17
Large ribosomal subunit protein uL22

1

4

High-throughput

0.536

High

686432

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.536

High

785454

RL4
Large ribosomal subunit protein uL4

1

4

High-throughput

0.536

High

855217

NOP2
28S rRNA

1

3

High-throughput

0.536

High

859456

RL5
Large ribosomal subunit protein uL18

1

5

High-throughput

0.536

High

860003

RL28
Large ribosomal subunit protein eL28

1

1

High-throughput

0.536

High

884233

SRP09
Signal recognition particle 9 kDa protein

1

4

High-throughput

0.536

High

898820

RL14
Large ribosomal subunit protein eL14

1

2

High-throughput

0.536

High

960893

RL15
Large ribosomal subunit protein eL15

1

3

High-throughput

0.536

High

978727

RL23A
Large ribosomal subunit protein uL23

1

4

High-throughput

0.536

High

979243

RS6
Small ribosomal subunit protein eS6

1

5

High-throughput

0.536

High

984989

RL31
Large ribosomal subunit protein eL31

1

6

High-throughput

0.536

High

986212

RL8
Large ribosomal subunit protein uL2

1

2

High-throughput

0.536

High

1038477

TIE2
Angiopoietin-1 receptor

1

3

High-throughput

0.536

High

1099536

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.536

High

1111273

SNW1
SNW domain-containing protein 1

1

7

High-throughput

0.536

High

1124546

MAP7
Ensconsin

1

13

High-throughput

0.536

High

1148791

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

14

High-throughput

0.536

High

1245500

CC137
Coiled-coil domain-containing protein 137

1

1

High-throughput

0.536

High

1360480

PSPC1
Paraspeckle component 1

1

20

High-throughput

0.536

High

1395819

ZC3HA
Zinc finger CCCH domain-containing protein 10

1

1

High-throughput

0.536

High

1409840

RBM4B
RNA-binding protein 4B

1

8

High-throughput

0.536

High

1435117

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

6

High-throughput

0.536

High

1435132

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

5

High-throughput

0.536

High

1435136

RBM19
Probable RNA-binding protein 19

1

15

High-throughput

0.536

High

1123819

DCTN1
Dynactin subunit 1

2

3

High-throughput

0.533

High

1229084

RNF43
E3 ubiquitin-protein ligase RNF43

2

1

High-throughput

0.533

High

396951

ESR1
Estrogen receptor

2

20

High-throughput

0.521

High

1295558

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.517

High

72811

B0UZZ8
WD repeat-containing protein 46

1

14

High-throughput

0.514

High

1411809

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

419206

H2A1B
Histone H2A type 1-B/E

1

13

High-throughput

0.489

High

502537

H2A1
Histone H2A type 1

1

13

High-throughput

0.489

High

517820

GLI4
Zinc finger protein GLI4

1

5

High-throughput

0.489

High

657309

KALM
Anosmin-1

1

1

High-throughput

0.489

High

833191

MNDA
Myeloid cell nuclear differentiation antigen

1

16

High-throughput

0.489

High

1127494

FGFP1
Fibroblast growth factor-binding protein 1

1

3

High-throughput

0.489

High

1144162

TEBP
Prostaglandin E synthase 3

1

4

High-throughput

0.489

High

1178088

RN151
RING finger protein 151

1

7

High-throughput

0.489

High

1252678

ZN574
Zinc finger protein 574

1

3

High-throughput

0.489

High

1278636

HEAT3
HEAT repeat-containing protein 3

1

2

High-throughput

0.489

High

1281474

ZN467
Zinc finger protein 467

1

2

High-throughput

0.489

High

1291211

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

7

High-throughput

0.489

High

1313148

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

2

High-throughput

0.489

High

1370537

FGF13
Fibroblast growth factor 13

1

12

High-throughput

0.489

High

1382531

TRI52
E3 ubiquitin-protein ligase TRIM52

1

7

High-throughput

0.489

High

1385978

ZN653
Zinc finger protein 653

1

4

High-throughput

0.489

High

1387891

PABP5
Polyadenylate-binding protein 5

1

9

High-throughput

0.489

High

1390614

NEIL1
Endonuclease 8-like 1

1

3

High-throughput

0.489

High

1392746

ZN764
Zinc finger protein 764

1

4

High-throughput

0.489

High

1395705

ZN668
Zinc finger protein 668

1

3

High-throughput

0.489

High

1398582

ZNF48
Zinc finger protein 48

1

1

High-throughput

0.489

High

1403428

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1435108

UBP42
Ubiquitin carboxyl-terminal hydrolase 42

1

8

High-throughput

0.489

High

1435111

CBX8
Chromobox protein homolog 8

1

9

High-throughput

0.489

High

1435137

MB212
Protein mab-21-like 2

1

6

High-throughput

0.489

High

157855

CTRO
Citron Rho-interacting kinase

1

12

High-throughput

0.479

High

320056

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

373153

MYC
Myc proto-oncogene protein

1

16

High-throughput

0.479

High

412616

NTRK1
High affinity nerve growth factor receptor

1

13

High-throughput

0.479

High

461938

HS90A
Heat shock protein HSP 90-alpha

1

7

Small-scale

0.479

High

473084

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

20

High-throughput

0.479

High

487760

PARP1
Poly [ADP-ribose] polymerase 1

1

14

High-throughput

0.479

High

558405

XRCC6
X-ray repair cross-complementing protein 6

1

6

High-throughput

0.479

High

610049

VGFR1
Vascular endothelial growth factor receptor 1

1

7

High-throughput

0.479

High

643072

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

4

High-throughput

0.479

High

696511

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.479

High

716229

ERP29
Endoplasmic reticulum resident protein 29

1

1

High-throughput

0.479

High

777768

VGFR3
Vascular endothelial growth factor receptor 3

1

7

High-throughput

0.479

High

787077

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

7

High-throughput

0.479

High

831434

CCNF
Cyclin-F

1

7

High-throughput

0.479

High

891313

GSK3A
Glycogen synthase kinase-3 alpha

1

9

High-throughput

0.479

High

891789

GSK3B
Glycogen synthase kinase-3 beta

1

12

High-throughput

0.479

High

971084

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.479

High

1035918

KIF23
Kinesin-like protein KIF23

1

11

High-throughput

0.479

High

1087552

GRSF1
G-rich sequence factor 1

1

20

High-throughput

0.479

High

1096224

TADBP
TAR DNA-binding protein 43

1

12

High-throughput

0.479

High

1100384

TIF1B
Transcription intermediary factor 1-beta

1

20

High-throughput

0.479

High

1108155

SQSTM
Sequestosome-1

1

5

High-throughput

0.479

High

1140867

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1161674

IF16
Gamma-interferon-inducible protein 16

1

16

High-throughput

0.479

High

1207445

HABP4
Intracellular hyaluronan-binding protein 4

1

10

High-throughput

0.479

High

1215830

RC3H1
Roquin-1

1

11

High-throughput

0.479

High

1275676

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

14

High-throughput

0.479

High

1281611

SLN11
Schlafen family member 11

1

7

High-throughput

0.479

High

1290730

ZCH18
Zinc finger CCCH domain-containing protein 18

1

12

High-throughput

0.479

High

1316455

XRN1
5'-3' exoribonuclease 1

1

4

High-throughput

0.479

High

1329874

SIR6
NAD-dependent protein deacylase sirtuin-6

1

14

High-throughput

0.479

High

1330934

CGAS
Cyclic GMP-AMP synthase

1

6

High-throughput

0.479

High

1334923

SERB1
SERPINE1 mRNA-binding protein 1

1

10

High-throughput

0.479

High

1393697

DDRGK
DDRGK domain-containing protein 1

1

7

High-throughput

0.479

High

1407876

ANM1
Protein arginine N-methyltransferase 1

1

7

High-throughput

0.479

High

1418586

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

16

High-throughput

0.479

High

1430167

SIK2
Serine/threonine-protein kinase SIK2

1

3

Small-scale

0.479

High

1435110

RC3H2
Roquin-2

1

14

High-throughput

0.479

High

1435118

LYAR
Cell growth-regulating nucleolar protein

1

3

High-throughput

0.479

High

1435120

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

10

High-throughput

0.479

High

1435129

CC14A
Dual specificity protein phosphatase CDC14A

1

6

High-throughput

0.479

High

1435130

RL26L
Ribosomal protein uL24-like

1

6

High-throughput

0.479

High

1435128

MYO6
Unconventional myosin-VI

1

0

Small-scale

0.458

High

951854

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

High-throughput

0.457

High

1435116

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.457

High

414631

P53
Cellular tumor antigen p53

1

7

Small-scale

0.445

High

430364

JUN
Transcription factor Jun

1

11

High-throughput

0.445

High

960253

RL26
Large ribosomal subunit protein uL24

1

6

High-throughput

0.445

High

1056975

FMR1
Fragile X messenger ribonucleoprotein 1

1

8

High-throughput

0.445

High

1112177

KRR1
KRR1 small subunit processome component homolog

1

5

High-throughput

0.445

High

1126839

SLBP
Histone RNA hairpin-binding protein

1

1

High-throughput

0.445

High

1209661

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

1252518

LN28B
Protein lin-28 homolog B

1

18

High-throughput

0.445

High

1348850

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

17

High-throughput

0.445

High

1407164

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

1

High-throughput

0.445

High

1411549

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.445

High

1413983

MMTA2
Multiple myeloma tumor-associated protein 2

1

2

High-throughput

0.445

High

1430329

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

19

High-throughput

0.445

High

1430422

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

3

High-throughput

0.445

High

132300

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

11

High-throughput

0.437

High

174613

TRI66
Tripartite motif-containing protein 66

1

20

High-throughput

0.437

High

180927

TIF1A
Transcription intermediary factor 1-alpha

1

20

Small-scale

0.437

High

325114

HEXI1
Protein HEXIM1

1

5

High-throughput

0.437

High

406644

MYCN
N-myc proto-oncogene protein

1

16

High-throughput

0.437

High

589692

RFA2
Replication protein A 32 kDa subunit

1

13

High-throughput

0.437

High

769183

RFA3
Replication protein A 14 kDa subunit

1

11

High-throughput

0.437

High

872749

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.437

High

1126178

GRM2
Metabotropic glutamate receptor 2

1

3

High-throughput

0.437

High

1141941

EEA1
Early endosome antigen 1

1

14

High-throughput

0.437

High

1276791

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

11

High-throughput

0.437

High

1289632

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.437

High

1324918

RHG18
Rho GTPase-activating protein 18

1

2

High-throughput

0.437

High

1327198

FBXL6
F-box/LRR-repeat protein 6

1

5

High-throughput

0.437

High

1332897

KDF1
Keratinocyte differentiation factor 1

1

3

High-throughput

0.437

High

1338374

FBX22
F-box only protein 22

1

1

High-throughput

0.437

High

1357560

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

1363849

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

1

High-throughput

0.437

High

1367279

ESR2
Estrogen receptor beta

1

19

High-throughput

0.437

High

1401394

CIC
Protein capicua homolog

1

14

High-throughput

0.437

High

1430583

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.437

High

1433892

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.437

High

1435112

BRD7
Bromodomain-containing protein 7

1

19

High-throughput

0.437

High

1435113

ANLN
Anillin

1

7

High-throughput

0.437

High

1435115

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

14

High-throughput

0.437

High

1435127

FZR1
Fizzy-related protein homolog

1

20

High-throughput

0.437

High

1435138

MAFB
Transcription factor MafB

1

12

High-throughput

0.437

High

181175

AXIN1
Axin-1

1

0

Small-scale

0.426

High

1337417

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.426

High

1435133

S27A5
Long-chain fatty acid transport protein 5

1

0

High-throughput

0.426

High

328158

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

19

High-throughput

0.407

High

1037371

H11
Histone H1.1

1

20

High-throughput

0.407

High

1157686

CRY1
Cryptochrome-1

1

2

Small-scale

0.407

High

1315250

CA174
UPF0688 protein C1orf174

1

2

High-throughput

0.407

High

1327333

ZN276
Zinc finger protein 276

1

5

High-throughput

0.407

High

1328527

RNF10
E3 ubiquitin-protein ligase RNF10

1

3

High-throughput

0.407

High

1420716

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

1145841

IRF4
Interferon regulatory factor 4

1

0

High-throughput

0.306

High

483216

CLCA
Clathrin light chain A

1

0

High-throughput

0.279

Low

852116

TNNT3
Troponin T, fast skeletal muscle

1

0

High-throughput

0.279

Low

946319

NXPH1
Neurexophilin-1

1

0

High-throughput

0.279

Low

1292833

TEN1L
CST complex subunit TEN1

1

0

High-throughput

0.279

Low

1435121

C2D2A
Coiled-coil and C2 domain-containing protein 2A

1

0

High-throughput

0.249

Low

1063076

S20A2
Sodium-dependent phosphate transporter 2

1

0

High-throughput

0.232

Low

1244331

PSRC1
Proline/serine-rich coiled-coil protein 1

1

0

High-throughput

0.232

Low

1288454

SO6A1
Solute carrier organic anion transporter family member 6A1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025