HitPredict

Interactor 1: M3K10 (Q02779)
Mitogen-activated protein kinase kinase kinase 10 (EC 2.7.11.25) (Mixed lineage kinase 2) (Protein kinase MST)
Gene: MAP3K10

Interactor 2: M3K21 (Q5TCX8)
Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)
Gene: MAP3K21

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.66 1.00 0.817

The method score is based on:

Property Details
Experiments 32707033, 20936779
Identification Methods affinity chromatography technology, two hybrid, pull down, two hybrid pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains PK_Tyr_Ser-Thr~PK_Tyr_Ser-Thr, PK_Tyr_Ser-Thr~SH3_9, SH3_9~SH3_9
Common GO terms GO:0004672 - protein kinase activity
GO:0004706 - JUN kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0007165 - signal transduction
and 3 others

more...
Homologous interactions 19

Homologous interactions

Color coding for hit scores

1 954
Hs

1 1036
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+ Ce

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Last updated: 15 Jul 2024