HitPredict

Interactor 1: AKA12 (Q02952)
A-kinase anchor protein 12 (AKAP-12) (A-kinase anchor protein 250 kDa) (AKAP 250) (Gravin) (Myasthenia gravis autoantigen)
Gene: AKAP12

Interactor 2: RHOU (Q7L0Q8)
Rho-related GTP-binding protein RhoU (CDC42-like GTPase 1) (GTP-binding protein-like 1) (Rho GTPase-like protein ARHU) (Ryu GTPase) (Wnt-1 responsive Cdc42 homolog 1) (WRCH-1)
Gene: RHOU

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0005925 - focal adhesion
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 1782 Hs			1 258
+	Hs
		892327 AKA12_HUMAN (1-1782): 0: 676: 100.00		RAC3_HUMAN (48-223): 1.28e-83: 249: 57.96
+	Hs
		950936 AKA12_HUMAN (1-1782): 0: 676: 100.00		RHOG_HUMAN (48-233): 5.28e-83: 248: 48.93
+	Hs
		925213 AKA12_HUMAN (1-1782): 0: 676: 100.00		RAC1_HUMAN (50-234): 2.11e-79: 239: 56.76
+	Hs
		914019 AKA12_HUMAN (1-1782): 0: 676: 100.00		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		900397 AKA12_HUMAN (1-1782): 0: 676: 100.00		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		545332 AKA12_HUMAN (1-1782): 0: 676: 100.00		RAC2_HUMAN (50-233): 5.11e-77: 233: 56.52
+	Hs
		893919 AKA12_HUMAN (1-1782): 0: 676: 100.00		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		564487 AKA12_HUMAN (1-1782): 0: 676: 100.00		RHOQ_HUMAN (50-221): 2.69e-66: 206: 56.40
+	Hs
		973796 AKA12_HUMAN (1-1782): 0: 676: 100.00		RHOJ_HUMAN (40-238): 2.64e-63: 199: 51.26
+	Ce
		136793 UNC89_CAEEL (4-1099): 1.99e-70: 266: 12.94		RAC1_CAEEL (50-233): 1.71e-78: 236: 55.98
+	Ce
		104464 UNC89_CAEEL (4-1099): 1.99e-70: 266: 12.94		G5EBV3_CAEEL (44-233): 4.44e-77: 233: 49.47
+	Ce
		136794 UNC89_CAEEL (4-1099): 1.99e-70: 266: 12.94		CDC42_CAEEL (50-236): 3.05e-74: 226: 58.82
+	Hs
		914253 TITIN_HUMAN (21-962): 3.34e-13: 77.6: 11.72		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		801060 KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31		RB11A_HUMAN (39-256): 1.13e-77: 235: 26.87
+	Hs
		801053 KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31		RHOA_HUMAN (51-232): 1.24e-77: 234: 46.15
+	Hs
		801049 KI67_HUMAN (1-1782): 2.94e-11: 71.2: 11.31		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82
+	Hs
		894572 MUC12_HUMAN (4-386): 4.43e-10: 67.3: 6.79		CDC42_HUMAN (50-236): 2.23e-74: 226: 58.82