Protein: SF3B4
Splicing factor 3B subunit 4 (Pre-mRNA-splicing factor SF3b 49 kDa subunit) (Spliceosome-associated protein 49) (SAP 49)

Gene: SF3B4
Organism: Homo sapiens
Interactions: 224
UniProt ID: Q15427

Gene Ontology (top 5):
GO:0000375 - RNA splicing, via transesterification reactions
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1105292

SF3B2
Splicing factor 3B subunit 2

10

6

Small-scale

0.978

High

1023073

RBM10
RNA-binding protein 10

4

20

High-throughput

0.911

High

853797

MK09
Mitogen-activated protein kinase 9

4

12

High-throughput

0.911

High

1126905

RBM39
RNA-binding protein 39

3

19

High-throughput

0.873

High

485639

RU2A
U2 small nuclear ribonucleoprotein A'

3

3

High-throughput

0.861

High

285932

SF3B1
Splicing factor 3B subunit 1

3

1

Small-scale

0.847

High

1148494

SF3A2
Splicing factor 3A subunit 2

3

5

Small-scale

0.847

High

471843

RU2B
U2 small nuclear ribonucleoprotein B''

2

20

High-throughput

0.811

High

1148579

SF3B6
Splicing factor 3B subunit 6

2

17

High-throughput

0.789

High

1148539

SPF45
Splicing factor 45

2

16

High-throughput

0.776

High

1032987

EWS
RNA-binding protein EWS

2

16

High-throughput

0.757

High

1148522

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

15

High-throughput

0.757

High

1148502

LARP7
La-related protein 7

2

19

High-throughput

0.754

High

908116

KS6A3
Ribosomal protein S6 kinase alpha-3

2

7

High-throughput

0.737

High

274002

CREST
Calcium-responsive transactivator

4

1

High-throughput

0.705

High

347712

BAG3
BAG family molecular chaperone regulator 3

4

4

High-throughput

0.699

High

136090

PLK4
Serine/threonine-protein kinase PLK4

1

8

High-throughput

0.691

High

478059

SNRPA
U1 small nuclear ribonucleoprotein A

1

20

High-throughput

0.691

High

625402

CSK22
Casein kinase II subunit alpha'

1

8

High-throughput

0.691

High

1016455

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.691

High

1147885

SF3B3
Splicing factor 3B subunit 3

1

3

High-throughput

0.691

High

1148574

ZN346
Zinc finger protein 346

1

8

High-throughput

0.691

High

1148576

SRPK3
SRSF protein kinase 3

1

20

High-throughput

0.691

High

787168

BMR1A
Bone morphogenetic protein receptor type-1A

2

0

Small-scale

0.678

High

1148499

C19L2
CWF19-like protein 2

3

3

High-throughput

0.675

High

973922

RUXF
Small nuclear ribonucleoprotein F

3

7

High-throughput

0.675

High

1148518

DDX42
ATP-dependent RNA helicase DDX42

3

9

High-throughput

0.664

High

729282

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

16

High-throughput

0.656

High

912896

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

18

High-throughput

0.656

High

1099361

SRSF6
Serine/arginine-rich splicing factor 6

1

20

High-throughput

0.656

High

1120164

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

20

High-throughput

0.656

High

1148497

SF01
Splicing factor 1

1

13

High-throughput

0.656

High

1148555

RBM4
RNA-binding protein 4

1

17

High-throughput

0.656

High

685583

U2AF2
Splicing factor U2AF 65 kDa subunit

1

19

Small-scale

0.647

High

1148562

MET17
Ribosome assembly protein METTL17, mitochondrial

2

1

High-throughput

0.646

High

222086

NCK2
Cytoplasmic protein NCK2

4

16

High-throughput

0.644

High

841012

FRK
Tyrosine-protein kinase FRK

2

9

High-throughput

0.640

High

1148552

HNRL1
Heterogeneous nuclear ribonucleoprotein U-like protein 1

2

8

High-throughput

0.640

High

1138236

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

6

High-throughput

0.631

High

1148508

PRP8
Pre-mRNA-processing-splicing factor 8

2

4

High-throughput

0.631

High

574282

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

2

7

High-throughput

0.628

High

991183

RSMN
Small nuclear ribonucleoprotein-associated protein N

2

8

High-throughput

0.628

High

1148507

ANM9
Protein arginine N-methyltransferase 9

2

13

Small-scale

0.628

High

1148514

PHF5A
PHD finger-like domain-containing protein 5A

2

1

High-throughput

0.628

High

1148543

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

2

High-throughput

0.628

High

211325

RFOX2
RNA binding protein fox-1 homolog 2

1

19

High-throughput

0.621

High

655209

SFPQ
Splicing factor, proline- and glutamine-rich

1

17

High-throughput

0.621

High

909006

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.618

High

134747

SAP18
Histone deacetylase complex subunit SAP18

1

4

High-throughput

0.618

High

349090

LATS1
Serine/threonine-protein kinase LATS1

1

9

High-throughput

0.618

High

472757

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

17

High-throughput

0.618

High

775106

FUS
RNA-binding protein FUS

1

20

High-throughput

0.618

High

877120

KC1D
Casein kinase I isoform delta

1

1

High-throughput

0.618

High

889112

RBM25
RNA-binding protein 25

1

3

High-throughput

0.618

High

1088670

SF3A3
Splicing factor 3A subunit 3

1

1

High-throughput

0.618

High

1148523

RB15B
Putative RNA-binding protein 15B

1

16

High-throughput

0.618

High

1148527

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

2

High-throughput

0.618

High

1148529

PSPC1
Paraspeckle component 1

1

19

High-throughput

0.618

High

1148538

AURKB
Aurora kinase B

1

14

High-throughput

0.618

High

1148542

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

3

High-throughput

0.618

High

1148572

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.618

High

974133

RUXG
Small nuclear ribonucleoprotein G

2

13

High-throughput

0.611

High

1148570

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

2

0

High-throughput

0.608

High

600498

ZNF3
Zinc finger protein 3

2

1

High-throughput

0.606

High

1148554

TRAF4
TNF receptor-associated factor 4

2

9

High-throughput

0.606

High

973725

RUXE
Small nuclear ribonucleoprotein E

2

0

High-throughput

0.602

High

1139917

RRS1
Ribosome biogenesis regulatory protein homolog

2

0

High-throughput

0.602

High

1148537

CCD97
Coiled-coil domain-containing protein 97

2

0

High-throughput

0.602

High

280631

PR40A
Pre-mRNA-processing factor 40 homolog A

2

20

High-throughput

0.595

High

97136

E9PPJ0
Splicing factor 3b subunit 2

1

6

High-throughput

0.594

High

987658

GRB2
Growth factor receptor-bound protein 2

2

14

High-throughput

0.586

High

241762

PRKN
E3 ubiquitin-protein ligase parkin

2

19

High-throughput

0.584

High

345864

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

20

High-throughput

0.584

High

1061704

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1148541

ZNF48
Zinc finger protein 48

2

0

High-throughput

0.580

High

1148550

RAMAC
RNA guanine-N7 methyltransferase activating subunit

2

0

High-throughput

0.580

High

1148553

RPP25
Ribonuclease P protein subunit p25

2

0

High-throughput

0.580

High

1148564

LN28A
Protein lin-28 homolog A

1

20

High-throughput

0.575

High

1148548

WDR83
WD repeat domain-containing protein 83

1

9

High-throughput

0.573

High

943767

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

1

6

High-throughput

0.573

High

1148571

HSPB7
Heat shock protein beta-7

1

4

High-throughput

0.573

High

1148578

BAIP2
BAR/IMD domain-containing adapter protein 2

1

2

High-throughput

0.573

High

335849

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

2

0

Small-scale

0.569

High

1148532

TFG
Protein TFG

2

7

High-throughput

0.553

High

157415

CTRO
Citron Rho-interacting kinase

1

17

High-throughput

0.553

High

207548

DHX15
ATP-dependent RNA helicase DHX15

2

6

Small-scale

0.552

High

297991

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.549

High

1148582

NUB1
NEDD8 ultimate buster 1

1

0

High-throughput

0.549

High

944149

WDR4
tRNA

1

14

High-throughput

0.541

High

251586

CCNT1
Cyclin-T1

1

3

High-throughput

0.536

High

298387

DNJC8
DnaJ homolog subfamily C member 8

1

1

High-throughput

0.536

High

480149

RU1C
U1 small nuclear ribonucleoprotein C

1

4

High-throughput

0.536

High

595783

H13
Histone H1.3

1

14

High-throughput

0.536

High

809650

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

951982

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

7

High-throughput

0.536

High

974561

SMD2
Small nuclear ribonucleoprotein Sm D2

1

2

High-throughput

0.536

High

1111001

SNW1
SNW domain-containing protein 1

1

7

High-throughput

0.536

High

1112500

CUL1
Cullin-1

1

20

High-throughput

0.536

High

1113176

CUL3
Cullin-3

1

20

High-throughput

0.536

High

1148495

SF3A1
Splicing factor 3A subunit 1

1

5

High-throughput

0.536

High

1148500

P3H1
Prolyl 3-hydroxylase 1

1

1

High-throughput

0.536

High

1148506

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

1

High-throughput

0.536

High

1148516

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

14

High-throughput

0.536

High

1148528

STYX
Serine/threonine/tyrosine-interacting protein

1

6

High-throughput

0.536

High

1148534

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.536

High

1148544

CDC5L
Cell division cycle 5-like protein

1

5

Small-scale

0.536

High

1148556

SF3B5
Splicing factor 3B subunit 5

1

1

High-throughput

0.536

High

1148557

NADAP
Kanadaptin

1

1

High-throughput

0.536

High

1148565

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

2

High-throughput

0.536

High

1124599

SRC8
Src substrate cortactin

2

5

High-throughput

0.535

High

319099

SC24D
Protein transport protein Sec24D

1

1

High-throughput

0.523

High

298518

SPF30
Survival of motor neuron-related-splicing factor 30

1

5

High-throughput

0.515

High

642554

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1089675

ILF3
Interleukin enhancer-binding factor 3

1

20

High-throughput

0.508

High

1148519

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

6

High-throughput

0.508

High

1148533

DDX17
Probable ATP-dependent RNA helicase DDX17

1

9

High-throughput

0.508

High

1148546

MEP50
Methylosome protein WDR77

1

8

High-throughput

0.508

High

127089

APBB1
Amyloid beta precursor protein binding family B member 1

1

1

High-throughput

0.501

High

185721

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.501

High

286467

WBP4
WW domain-binding protein 4

1

10

High-throughput

0.501

High

292002

CRTAP
Cartilage-associated protein

1

1

High-throughput

0.489

High

964009

COPZ1
Coatomer subunit zeta-1

1

1

High-throughput

0.489

High

1013299

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

1148509

TTC33
Tetratricopeptide repeat protein 33

1

5

High-throughput

0.489

High

321544

PRP6
Pre-mRNA-processing factor 6

1

13

High-throughput

0.481

High

336673

BAG4
BAG family molecular chaperone regulator 4

1

4

High-throughput

0.481

High

996165

EF1A1
Elongation factor 1-alpha 1

1

11

High-throughput

0.481

High

1148504

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

1

13

High-throughput

0.481

High

1148540

DMRTB
Doublesex- and mab-3-related transcription factor B1

1

3

High-throughput

0.481

High

129108

MEN1
Menin

1

5

High-throughput

0.479

High

132060

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

11

High-throughput

0.479

High

138124

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

8

High-throughput

0.479

High

163776

TCRG1
Transcription elongation regulator 1

1

10

Small-scale

0.479

High

223071

PRC1
Protein regulator of cytokinesis 1

1

9

High-throughput

0.479

High

247925

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

259993

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.479

High

315619

RECQ4
ATP-dependent DNA helicase Q4

1

14

High-throughput

0.479

High

319789

UFL1
E3 UFM1-protein ligase 1

1

5

High-throughput

0.479

High

326958

UBE4B
Ubiquitin conjugation factor E4 B

1

1

Small-scale

0.479

High

330994

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

341572

EYA4
Protein phosphatase EYA4

1

9

High-throughput

0.479

High

362298

ABL1
Tyrosine-protein kinase ABL1

1

9

High-throughput

0.479

High

372101

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

396171

ESR1
Estrogen receptor

1

20

High-throughput

0.479

High

406211

MYCN
N-myc proto-oncogene protein

1

15

High-throughput

0.479

High

425519

ISG15
Ubiquitin-like protein ISG15

1

16

High-throughput

0.479

High

440571

FYN
Tyrosine-protein kinase Fyn

1

9

High-throughput

0.479

High

586710

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

594008

NCK1
SH2/SH3 adapter protein NCK1

1

16

High-throughput

0.479

High

606802

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

675509

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

731325

STIP1
Stress-induced-phosphoprotein 1

1

9

High-throughput

0.479

High

766579

PHB1
Prohibitin 1

1

9

High-throughput

0.479

High

767216

MERL
Merlin

1

2

High-throughput

0.479

High

830792

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

871941

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

2

High-throughput

0.479

High

879123

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

904752

MECP2
Methyl-CpG-binding protein 2

1

5

High-throughput

0.479

High

937760

FOXA1
Hepatocyte nuclear factor 3-alpha

1

2

High-throughput

0.479

High

970555

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

979705

H4
Histone H4

1

4

High-throughput

0.479

High

1004602

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1035642

KIF23
Kinesin-like protein KIF23

1

16

High-throughput

0.479

High

1121225

TRI14
Tripartite motif-containing protein 14

1

10

High-throughput

0.479

High

1137304

SUZ12
Polycomb protein SUZ12

1

2

High-throughput

0.479

High

1140316

KIF14
Kinesin-like protein KIF14

1

9

High-throughput

0.479

High

1148496

TERF2
Telomeric repeat-binding factor 2

1

2

High-throughput

0.479

High

1148505

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

1148510

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

1

High-throughput

0.479

High

1148513

MEPCE
7SK snRNA methylphosphate capping enzyme

1

7

High-throughput

0.479

High

1148515

ZCH18
Zinc finger CCCH domain-containing protein 18

1

9

High-throughput

0.479

High

1148520

SMC5
Structural maintenance of chromosomes protein 5

1

9

High-throughput

0.479

High

1148521

SRRM1
Serine/arginine repetitive matrix protein 1

1

4

High-throughput

0.479

High

1148524

TNIP2
TNFAIP3-interacting protein 2

1

4

High-throughput

0.479

High

1148526

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

5

High-throughput

0.479

High

1148530

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

5

High-throughput

0.479

High

1148531

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1148535

FGF11
Fibroblast growth factor 11

1

1

High-throughput

0.479

High

1148536

OPTN
Optineurin

1

12

High-throughput

0.479

High

1148545

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.479

High

1148547

RIOK1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

1148558

API5
Apoptosis inhibitor 5

1

1

High-throughput

0.479

High

1148559

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

17

High-throughput

0.479

High

1148560

NSRP1
Nuclear speckle splicing regulatory protein 1

1

2

High-throughput

0.479

High

1148566

BRD7
Bromodomain-containing protein 7

1

11

High-throughput

0.479

High

1148567

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

5

High-throughput

0.479

High

1148568

ANLN
Anillin

1

8

High-throughput

0.479

High

1148573

UBQL2
Ubiquilin-2

1

6

High-throughput

0.479

High

1148575

FZR1
Fizzy-related protein homolog

1

13

High-throughput

0.479

High

1148577

SRRM2
Serine/arginine repetitive matrix protein 2

1

12

High-throughput

0.479

High

1148580

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

1148583

MAFB
Transcription factor MafB

1

6

High-throughput

0.479

High

1081529

Q0VDC6
peptidylprolyl isomerase

1

2

High-throughput

0.470

High

1148498

ITSN1
Intersectin-1

1

3

High-throughput

0.464

High

1148569

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.460

High

1135684

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

1148551

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.458

High

71580

RUXGL
Putative small nuclear ribonucleoprotein G-like protein 15

1

13

High-throughput

0.445

High

429939

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

529852

TAU
Microtubule-associated protein tau

1

11

High-throughput

0.445

High

1119138

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

1148503

ODFP2
Outer dense fiber protein 2

1

3

High-throughput

0.445

High

1148517

S2611
Sodium-independent sulfate anion transporter

1

1

High-throughput

0.445

High

986854

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

2

High-throughput

0.439

High

891937

WHR1
Winged helix repair factor 1

1

0

Small-scale

0.438

High

293734

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.437

High

995612

ACTC
Actin, alpha cardiac muscle 1

1

7

High-throughput

0.437

High

1126087

GRM2
Metabotropic glutamate receptor 2

1

1

High-throughput

0.437

High

1134904

CUL7
Cullin-7

1

8

High-throughput

0.437

High

1148512

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.437

High

1148561

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.437

High

87466

OSCRI
SCRIB overlapping open reading frame protein

1

3

High-throughput

0.407

High

952181

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.407

High

1148563

GHC1
Mitochondrial glutamate carrier 1

1

3

High-throughput

0.407

High

1148581

TCAF1
TRPM8 channel-associated factor 1

5

0

High-throughput

0.378

High

868171

SYQ
Glutamine--tRNA ligase

2

0

High-throughput

0.316

High

1148525

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.299

High

566988

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.279

Low

720481

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

870187

GLIP1
Glioma pathogenesis-related protein 1

1

0

Small-scale

0.249

Low

1148501

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

1148511

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1148549

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

62528

S35F4
Solute carrier family 35 member F4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025