HitPredict

Interactor 1: HHEX (Q03014)
Hematopoietically-expressed homeobox protein HHEX (Homeobox protein HEX) (Homeobox protein PRH) (Proline-rich homeodomain protein)
Gene: HHEX

Interactor 2: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37302518
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0016055 - Wnt signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 270 Hs			1 772
+	Hs
		974243 HHEX_HUMAN (1-270): 3.48e-55: 180: 100.00		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		882122 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		679097 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE3_HUMAN (1-772): 0: 583: 100.00
+	Hs
		839732 LHX2_HUMAN (38-269): 7.77e-34: 128: 14.66		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		882121 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		679096 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		882123 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Hs
		980663 HESX1_HUMAN (13-208): 1.22e-32: 120: 19.29		TLE1_HUMAN (1-772): 0: 538: 77.42
+	Hs
		679098 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE4_HUMAN (1-772): 9.37e-179: 533: 80.65
+	Dm
		484925 HMH2_DROME (134-260): 1.3e-36: 136: 33.07		GROU_DROME (1-772): 4.17e-136: 421: 57.20
+	Dm
		558366 UBX_DROME (16-198): 6.61e-31: 120: 19.89		GROU_DROME (1-772): 4.17e-136: 421: 57.20
+	Hs
		974247 HHEX_HUMAN (1-270): 3.48e-55: 180: 100.00		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		839735 LHX2_HUMAN (38-269): 7.77e-34: 128: 14.66		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		882124 GSC_HUMAN (3-234): 4.48e-34: 125: 20.34		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Hs
		679101 TLX1_HUMAN (79-252): 1.22e-32: 123: 27.32		TLE5_HUMAN (1-200): 1.22e-100: 310: 62.19
+	Ce
		137665 UNC4_CAEEL (93-262): 6.27e-34: 125: 22.35		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09
+	Ce
		137669 HM09_CAEEL (108-214): 5.55e-33: 119: 36.45		UNC37_CAEEL (18-686): 7.48e-82: 275: 17.09
+	Mm
		192307 ALX4_MOUSE (56-267): 3.69e-32: 123: 16.82		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66
+	Mm
		678773 HXA2_MOUSE (30-256): 7.83e-32: 122: 20.17		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66
+	Mm
		223203 TLX3_MOUSE (42-251): 5.25e-31: 118: 27.11		TLE6_MOUSE (473-772): 7.97e-46: 174: 33.66