HitPredict

Interactor 1: CREM (Q03060)
cAMP-responsive element modulator (Inducible cAMP early repressor) (ICER)
Gene: CREM

Interactor 2: CSEN (Q9Y2W7)
Calsenilin (A-type potassium channel modulatory protein 3) (DRE-antagonist modulator) (DREAM) (Kv channel-interacting protein 3) (KChIP3)
Gene: KCNIP3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11094064
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific GO:0005634 - nucleus GO:0007165 - signal transduction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 345 Hs			1 256
+	Hs
		901302 CREM_HUMAN (1-345): 3.33e-113: 334: 100.00		NCALD_HUMAN (67-252): 1.56e-68: 211: 38.71
+	Hs
		950450 CREM_HUMAN (1-345): 3.33e-113: 334: 100.00		HPCA_HUMAN (67-252): 1.98e-67: 208: 39.25
+	Hs
		906759 CREM_HUMAN (1-345): 3.33e-113: 334: 100.00		NCS1_HUMAN (67-256): 1.71e-66: 206: 42.63
+	Hs
		740656 CREM_HUMAN (1-345): 3.33e-113: 334: 100.00		HPCL1_HUMAN (67-252): 3.96e-60: 190: 39.79
+	Hs
		557007 CREB1_HUMAN (1-344): 6.31e-85: 261: 56.94		CSEN_HUMAN (1-256): 5.86e-72: 222: 100.00
+	At
		1105922 ABI5_ARATH (281-345): 2.55e-11: 66.3: 32.31		CDPKB_ARATH (21-255): 4.41e-70: 224: 15.61
+	At
		1105919 AI5L6_ARATH (183-331): 8.31e-11: 64.7: 19.48		CDPKB_ARATH (21-255): 4.41e-70: 224: 15.61
+	At
		1154724 AI5L5_ARATH (223-343): 6.28e-12: 68.2: 20.66		CDPKW_ARATH (21-241): 1.83e-61: 203: 18.83
+	At
		1154723 AI5L6_ARATH (183-331): 8.31e-11: 64.7: 19.48		CDPKW_ARATH (21-241): 1.83e-61: 203: 18.83