HitPredict

Interactor 1: FGFR4 (Q03142)
Fibroblast growth factor receptor 4 (FGFR-4) (EC 2.7.10.1) (Protein-tyrosine kinase receptor MPK-11) (CD antigen CD334)
Gene: FGFR4

Interactor 2: KLOTB (Q99N32)
Beta-klotho (BKL) (BetaKlotho) (Klotho beta-like protein)
Gene: Klb

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	17623664, 17452648
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Glyco_hydro_1~I-set
Common GO terms	GO:0005886 - plasma membrane GO:0008284 - positive regulation of cell population proliferation GO:0008543 - fibroblast growth factor receptor signaling pathway GO:0017134 - fibroblast growth factor binding
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 799 Mm			1 1043
+	Hs
		608033 FGFR4_HUMAN (13-799): 0: 736: 90.60		KLOTB_HUMAN (1-1043): 0: 1367: 78.76
+	Hs
		601541 FGFR2_HUMAN (3-794): 0: 734: 55.10		KLOTB_HUMAN (1-1043): 0: 1367: 78.76
+	Mm
		555271 FGFR1_MOUSE (1-791): 0: 709: 54.33		KLOTB_MOUSE (1-1043): 0: 1379: 100.00
+	Hs
		609401 FGFR3_HUMAN (3-798): 0: 714: 59.20		KLOTB_HUMAN (1-1043): 0: 1367: 78.76
+	Hs
		508088 FGFR1_HUMAN (1-791): 0: 711: 54.33		KLOTB_HUMAN (1-1043): 0: 1367: 78.76
+	Mm
		192163 FGFR4_MOUSE (1-799): 0: 755: 100.00		KLOT_MOUSE (55-1025): 0: 1158: 45.08
+	Mm
		192164 FGFR3_MOUSE (3-782): 0: 722: 58.81		KLOT_MOUSE (55-1025): 0: 1158: 45.08
+	Mm
		192157 FGFR1_MOUSE (1-791): 0: 709: 54.33		KLOT_MOUSE (55-1025): 0: 1158: 45.08
+	Mm
		93854 E9QNJ9_MOUSE (3-782): 0: 709: 56.91		KLOT_MOUSE (55-1025): 0: 1158: 45.08
+	Mm
		192159 FGFR2_MOUSE (3-794): 0: 707: 55.10		KLOT_MOUSE (55-1025): 0: 1158: 45.08
+	Ce
		1014307 EGL15_CAEEL (11-242): 1.01e-24: 112: 16.17		Q18758_CAEEL (518-961): 6.95e-154: 467: 23.57