Protein: ARF1
ADP-ribosylation factor 1 (EC 3.6.5.2)

Gene: ARF1
Organism: Homo sapiens
Interactions: 213
UniProt ID: P84077

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0000287 - magnesium ion binding
GO:0002090 - regulation of receptor internalization
GO:0003723 - RNA binding
GO:0003924 - GTPase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

920555

ARFP2
Arfaptin-2

4

10

Small-scale

0.892

High

1014971

GGA3
ADP-ribosylation factor-binding protein GGA3

4

20

Small-scale

0.891

High

1014978

GGA1
ADP-ribosylation factor-binding protein GGA1

4

20

Small-scale

0.887

High

1014948

CYH2
Cytohesin-2

4

14

Small-scale

0.885

High

921640

COPB
Coatomer subunit beta

4

20

Small-scale

0.874

High

920623

ARFP1
Arfaptin-1

3

10

Small-scale

0.847

High

1014925

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

20

Small-scale

0.799

High

1014982

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

2

17

Small-scale

0.799

High

1014981

AP4E1
AP-4 complex subunit epsilon-1

2

20

Small-scale

0.783

High

125830

AP4M1
AP-4 complex subunit mu-1

2

2

Small-scale

0.757

High

1014875

ARF1
ADP-ribosylation factor 1

2

15

Small-scale

0.755

High

1014887

PLD1
Phospholipase D1

2

2

Small-scale

0.754

High

1014913

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

2

7

High-throughput

0.737

High

1014980

ASAP1
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1

1

14

Small-scale

0.692

High

612193

ARF4
ADP-ribosylation factor 4

1

15

High-throughput

0.691

High

958758

ARF3
ADP-ribosylation factor 3

1

15

High-throughput

0.691

High

1014876

ARF5
ADP-ribosylation factor 5

1

15

High-throughput

0.691

High

126092

AP3B1
AP-3 complex subunit beta-1

1

20

Small-scale

0.647

High

225799

AP1G1
AP-1 complex subunit gamma-1

1

20

Small-scale

0.647

High

243923

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

9

Small-scale

0.647

High

1014883

AP1B1
AP-1 complex subunit beta-1

1

20

Small-scale

0.647

High

1014941

PKHA8
Pleckstrin homology domain-containing family A member 8

1

8

Small-scale

0.647

High

1014950

AGAP2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2

1

17

Small-scale

0.647

High

1014977

GGA2
ADP-ribosylation factor-binding protein GGA2

1

20

Small-scale

0.647

High

375402

RASK
GTPase KRas

3

20

High-throughput

0.640

High

701452

5HT2A
5-hydroxytryptamine receptor 2A

2

3

Small-scale

0.624

High

158808

AP3D1
AP-3 complex subunit delta-1

1

20

High-throughput

0.618

High

254481

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

3

Small-scale

0.618

High

552562

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.618

High

873204

COPD
Coatomer subunit delta

1

7

High-throughput

0.618

High

974977

ARF6
ADP-ribosylation factor 6

1

17

High-throughput

0.618

High

1014899

HERC1
Probable E3 ubiquitin-protein ligase HERC1

1

7

Small-scale

0.618

High

1014904

RHG21
Rho GTPase-activating protein 21

1

8

Small-scale

0.618

High

1014924

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

20

High-throughput

0.618

High

1014963

PKHA4
Pleckstrin homology domain-containing family A member 4

1

17

High-throughput

0.618

High

1014966

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

20

High-throughput

0.618

High

1014985

GIT1
ARF GTPase-activating protein GIT1

1

14

Small-scale

0.618

High

1014988

COPG1
Coatomer subunit gamma-1

1

19

Small-scale

0.618

High

168842

PLD2
Phospholipase D2

2

2

Small-scale

0.602

High

1014987

TRPV2
Transient receptor potential cation channel subfamily V member 2

1

1

Small-scale

0.590

High

630765

RAB4A
Ras-related protein Rab-4A

2

20

High-throughput

0.584

High

1014907

LTOR1
Ragulator complex protein LAMTOR1

2

6

High-throughput

0.584

High

410767

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

15

High-throughput

0.576

High

1014900

RHG31
Rho GTPase-activating protein 31

2

10

High-throughput

0.571

High

630152

ACM3
Muscarinic acetylcholine receptor M3

1

3

Small-scale

0.561

High

1014984

WBP11
WW domain-binding protein 11

1

3

High-throughput

0.541

High

135591

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.536

High

583534

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

4

High-throughput

0.536

High

619736

VCAM1
Vascular cell adhesion protein 1

1

3

High-throughput

0.536

High

640849

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

8

High-throughput

0.536

High

1014951

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

105757

APRIO
Alternative prion protein

2

1

Small-scale

0.533

High

687968

EF1G
Elongation factor 1-gamma

1

0

High-throughput

0.518

High

1014928

NOA1
Nitric oxide-associated protein 1

1

0

High-throughput

0.518

High

1014937

T106A
Transmembrane protein 106A

1

0

High-throughput

0.518

High

1014975

DUX4
Double homeobox protein 4

1

3

High-throughput

0.516

High

539796

RALA
Ras-related protein Ral-A

1

18

Small-scale

0.501

High

664967

ERD21
ER lumen protein-retaining receptor 1

1

3

Small-scale

0.501

High

948094

AP3S2
AP-3 complex subunit sigma-2

1

10

Small-scale

0.501

High

1014905

GORAB
RAB6-interacting golgin

1

2

Small-scale

0.501

High

1014910

DEN1B
DENN domain-containing protein 1B

1

7

Small-scale

0.501

High

1014930

DEN1A
DENN domain-containing protein 1A

1

7

Small-scale

0.501

High

1014942

SCYL1
N-terminal kinase-like protein

1

5

Small-scale

0.501

High

1014923

FBXW8
F-box/WD repeat-containing protein 8

1

4

Small-scale

0.500

High

484496

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

158179

COPE
Coatomer subunit epsilon

1

3

Small-scale

0.481

High

791290

SYUA
Alpha-synuclein

1

5

High-throughput

0.481

High

131949

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

6

Small-scale

0.479

High

189509

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

315464

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

341021

DIRA3
GTP-binding protein Di-Ras3

1

18

High-throughput

0.479

High

371760

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.479

High

373877

RASN
GTPase NRas

1

20

High-throughput

0.479

High

385085

K1C14
Keratin, type I cytoskeletal 14

1

6

High-throughput

0.479

High

389285

FINC
Fibronectin

1

3

High-throughput

0.479

High

400650

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.479

High

407425

K2C1
Keratin, type II cytoskeletal 1

1

2

High-throughput

0.479

High

417377

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

5

High-throughput

0.479

High

463451

LYN
Tyrosine-protein kinase Lyn

1

3

High-throughput

0.479

High

476296

K1C16
Keratin, type I cytoskeletal 16

1

6

High-throughput

0.479

High

507833

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.479

High

548474

MPRI
Cation-independent mannose-6-phosphate receptor

1

6

High-throughput

0.479

High

561990

LAMP2
Lysosome-associated membrane glycoprotein 2

1

10

High-throughput

0.479

High

565344

ITA4
Integrin alpha-4

1

7

High-throughput

0.479

High

566130

K1C10
Keratin, type I cytoskeletal 10

1

8

High-throughput

0.479

High

603928

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.479

High

611081

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

5

High-throughput

0.479

High

630495

RAB3B
Ras-related protein Rab-3B

1

18

High-throughput

0.479

High

666234

KPCL
Protein kinase C eta type

1

1

High-throughput

0.479

High

667770

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.479

High

715533

MARCS
Myristoylated alanine-rich C-kinase substrate

1

6

High-throughput

0.479

High

749000

RL9
Large ribosomal subunit protein uL6

1

1

High-throughput

0.479

High

761980

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.479

High

764657

CTNB1
Catenin beta-1

1

1

High-throughput

0.479

High

770844

OPRM
Mu-type opioid receptor

1

4

Small-scale

0.479

High

784582

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

1

High-throughput

0.479

High

785101

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.479

High

810045

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

837552

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

1

High-throughput

0.479

High

862800

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

9

Small-scale

0.479

High

894681

EMD
Emerin

1

2

High-throughput

0.479

High

900770

RAB5C
Ras-related protein Rab-5C

1

18

High-throughput

0.479

High

901765

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

951099

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

956249

RAB2A
Ras-related protein Rab-2A

1

20

High-throughput

0.479

High

970332

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

976200

RB11A
Ras-related protein Rab-11A

1

18

High-throughput

0.479

High

977932

RHOB
Rho-related GTP-binding protein RhoB

1

18

High-throughput

0.479

High

978869

RS6
Small ribosomal subunit protein eS6

1

1

High-throughput

0.479

High

1004027

CXAR
Coxsackievirus and adenovirus receptor

1

7

High-throughput

0.479

High

1010844

TMF1
TATA element modulatory factor

1

2

High-throughput

0.479

High

1014877

VIGLN
Vigilin

1

6

High-throughput

0.479

High

1014878

LAT1
Large neutral amino acids transporter small subunit 1

1

6

High-throughput

0.479

High

1014882

CKAP4
Cytoskeleton-associated protein 4

1

7

High-throughput

0.479

High

1014884

STX4
Syntaxin-4

1

8

High-throughput

0.479

High

1014886

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

9

High-throughput

0.479

High

1014888

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

1014889

STIM1
Stromal interaction molecule 1

1

1

High-throughput

0.479

High

1014893

RBM39
RNA-binding protein 39

1

7

High-throughput

0.479

High

1014894

EPN4
Clathrin interactor 1

1

5

High-throughput

0.479

High

1014895

GOGB1
Golgin subfamily B member 1

1

3

High-throughput

0.479

High

1014896

CUL7
Cullin-7

1

1

High-throughput

0.479

High

1014897

RAB35
Ras-related protein Rab-35

1

20

High-throughput

0.479

High

1014898

TRIPB
Thyroid receptor-interacting protein 11

1

10

High-throughput

0.479

High

1014901

PKHG6
Pleckstrin homology domain-containing family G member 6

1

4

High-throughput

0.479

High

1014902

PKHG4
Puratrophin-1

1

3

High-throughput

0.479

High

1014906

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1014909

CDC73
Parafibromin

1

4

High-throughput

0.479

High

1014912

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

1014915

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.479

High

1014917

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.479

High

1014918

GOLI
E3 ubiquitin-protein ligase RNF130

1

13

High-throughput

0.479

High

1014919

HORN
Hornerin

1

3

High-throughput

0.479

High

1014920

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

1

High-throughput

0.479

High

1014921

K319L
Dyslexia-associated protein KIAA0319-like protein

1

4

High-throughput

0.479

High

1014922

CXD3
Gap junction delta-3 protein

1

3

High-throughput

0.479

High

1014926

DHB11
Estradiol 17-beta-dehydrogenase 11

1

7

High-throughput

0.479

High

1014927

RN149
E3 ubiquitin-protein ligase RNF149

1

11

High-throughput

0.479

High

1014929

GOGA5
Golgin subfamily A member 5

1

12

High-throughput

0.479

High

1014931

PARD3
Partitioning defective 3 homolog

1

7

High-throughput

0.479

High

1014933

AKAP1
A-kinase anchor protein 1, mitochondrial

1

4

High-throughput

0.479

High

1014934

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

1014935

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

4

High-throughput

0.479

High

1014938

LRC59
Leucine-rich repeat-containing protein 59

1

4

High-throughput

0.479

High

1014939

CHM4C
Charged multivesicular body protein 4c

1

5

High-throughput

0.479

High

1014943

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

1014946

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

11

High-throughput

0.479

High

1014947

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1014953

BAG1
BAG family molecular chaperone regulator 1

1

3

High-throughput

0.479

High

1014954

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

5

High-throughput

0.479

High

1014956

OSB10
Oxysterol-binding protein-related protein 10

1

2

High-throughput

0.479

High

1014957

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

1014961

S38A1
Sodium-coupled neutral amino acid symporter 1

1

3

High-throughput

0.479

High

1014962

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

1014967

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

1014968

DUS22
Dual specificity protein phosphatase 22

1

9

High-throughput

0.479

High

1014972

WWOX
WW domain-containing oxidoreductase

1

4

High-throughput

0.479

High

1014973

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

1014974

PI4KB
Phosphatidylinositol 4-kinase beta

1

2

High-throughput

0.479

High

1014976

HOOK1
Protein Hook homolog 1

1

3

High-throughput

0.479

High

1014979

RAB21
Ras-related protein Rab-21

1

20

High-throughput

0.479

High

1014983

LAMP3
Lysosome-associated membrane glycoprotein 3

1

10

High-throughput

0.479

High

353246

AGR2
Anterior gradient protein 2 homolog

1

5

High-throughput

0.470

High

327223

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.458

High

426482

HMGN2
Non-histone chromosomal protein HMG-17

1

0

High-throughput

0.458

High

612600

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

941894

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

969792

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.458

High

973394

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

1014879

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.458

High

1014881

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.458

High

1014936

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.458

High

1014945

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1014964

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.458

High

146

A0A024R6X4
PLEKHG4

1

3

High-throughput

0.445

High

254965

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

2

High-throughput

0.445

High

429729

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

529620

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.445

High

765387

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.445

High

934461

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.445

High

954386

SNP25
Synaptosomal-associated protein 25

1

3

Small-scale

0.445

High

955913

RAB8A
Ras-related protein Rab-8A

1

18

Small-scale

0.445

High

1014885

STK4
Serine/threonine-protein kinase 4

1

8

High-throughput

0.445

High

1014890

CUL3
Cullin-3

1

3

High-throughput

0.445

High

1014891

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.445

High

1014892

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

3

High-throughput

0.445

High

1014944

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

9

High-throughput

0.445

High

1014952

SEPT5
Septin-5

1

3

Small-scale

0.445

High

1014959

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

3

High-throughput

0.445

High

418063

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

5

High-throughput

0.437

High

588462

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.437

High

695209

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.437

High

767955

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.437

High

1014880

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

1

High-throughput

0.437

High

1014911

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

1

3

High-throughput

0.437

High

1014914

RHG36
Rho GTPase-activating protein 36

1

12

High-throughput

0.437

High

1014932

TM263
Transmembrane protein 263

1

3

High-throughput

0.437

High

1014955

OVOL2
Transcription factor Ovo-like 2

1

3

Small-scale

0.437

High

1014958

LNP
Endoplasmic reticulum junction formation protein lunapark

1

2

High-throughput

0.437

High

1014960

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

5

High-throughput

0.437

High

1014969

TB22B
TBC1 domain family member 22B

1

10

High-throughput

0.437

High

1014970

ELOV5
Very long chain fatty acid elongase 5

1

1

High-throughput

0.437

High

1014986

AAR2
Protein AAR2 homolog

1

3

High-throughput

0.437

High

847987

RAD52
DNA repair protein RAD52 homolog

1

0

Small-scale

0.426

High

773859

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

1014916

COX15
Heme A synthase COX15

1

0

High-throughput

0.279

Low

1014940

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.279

Low

847502

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.249

Low

1014908

TET2
Methylcytosine dioxygenase TET2

1

0

Small-scale

0.249

Low

1014949

SEC62
Translocation protein SEC62

1

0

High-throughput

0.249

Low

1014965

SHCAF
SIN3-HDAC complex-associated factor

1

0

Small-scale

0.249

Low

1014903

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025