HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: SNF5 (Q12824)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (BRG1-associated factor 47) (BAF47) (Integrase interactor 1 protein) (SNF5 homolog) (hSNF5)
Gene: SMARCB1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	12453419, 10490642
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045815 - transcription initiation-coupled chromatin remodeling GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 3969 Hs			1 385
+	Hs
		1017260 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		SNF5_HUMAN (1-385): 0: 658: 100.00
+	Hs
		1017136 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		SNF5_HUMAN (1-385): 0: 658: 100.00
+	Dm
		594801 TRX_DROME (3633-3969): 3.49e-71: 270: 43.54		Q24090_DROME (4-385): 0: 564: 65.54
+	Hs
		1017175 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		SNF5_HUMAN (1-385): 0: 658: 100.00