Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: DPY30 (Q9C005)
Protein dpy-30 homolog (Dpy-30-like protein) (Dpy-30L)
Gene: DPY30

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.66 0.60 0.633

The method score is based on:

Property Details
Experiments 31685992, 24981860, 17500065
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains -
Common GO terms GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0035097 - histone methyltransferase complex
GO:0042803 - protein homodimerization activity
GO:0045815 - transcription initiation-coupled chromatin remodeling
and 1 others

more...

Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 3969
Hs

1 99
+ Hs
+ Hs
+ Dm
+ Hs
+ Sp
+ Hs
+ Hs

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Last updated: 15 Jul 2024