HitPredict

Interactor 1: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Interactor 2: SKI8 (Q9GZS3)
Superkiller complex protein 8 (Ski8) (Meiotic recombination REC14 protein homolog) (WD repeat-containing protein 61) [Cleaved into: Superkiller complex protein 8, N-terminally processed (WD repeat-containing protein 61, N-terminally processed)]
Gene: SKIC8

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	20541477
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SET~WD40
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3969 Hs			1 305
+	Hs
		975303 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Hs
		975304 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		903149 KMT2A_HUMAN (1-3969): 0: 3187: 100.00		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		1080314 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		SKI8_HUMAN (1-305): 2.86e-101: 300: 100.00
+	Hs
		1288387 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		903604 KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		1080207 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		FBXW7_HUMAN (91-303): 1.6e-63: 214: 24.30
+	Hs
		1317584 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		NLE1_HUMAN (7-304): 9.15e-91: 279: 21.61
+	Hs
		209441 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		PLRG1_HUMAN (4-217): 2.47e-43: 156: 22.52
+	At
		1319861 ATX1_ARATH (3430-3969): 9.67e-101: 354: 21.12		WDR5A_ARATH (184-303): 3.4e-37: 136: 32.80
+	Hs
		1288291 SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		331862 NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		267764 EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54		TAF5L_HUMAN (24-208): 1.33e-09: 60.8: 25.76
+	Hs
		203735 SUV91_HUMAN (3630-3968): 1.07e-83: 284: 18.97		DAW1_HUMAN (182-303): 5.93e-35: 132: 26.02
+	Hs
		1288292 NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68		SNR40_HUMAN (2-216): 4.5e-59: 194: 22.42
+	Hs
		903609 SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Dm
		1129076 SET1_DROME (3423-3969): 3.44e-81: 301: 21.22		WDS_DROME (2-95): 1.13e-16: 81.2: 21.88
+	Hs
		165657 SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Hs
		903374 KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23		WDR5_HUMAN (179-304): 4.63e-41: 147: 33.33
+	Mm
		903669 KMT2C_MOUSE (337-1407): 2.62e-09: 66: 9.21		WDR5_MOUSE (179-304): 4.63e-41: 147: 33.33