HitPredict

Interactor 1: PPARD (Q03181)
Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta)
Gene: PPARD

Interactor 2: NCOA1 (Q15788)
Nuclear receptor coactivator 1 (NCoA-1) (EC 2.3.1.48) (Class E basic helix-loop-helix protein 74) (bHLHe74) (Protein Hin-2) (RIP160) (Renal carcinoma antigen NY-REN-52) (Steroid receptor coactivator 1) (SRC-1)
Gene: NCOA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.916

Property	Details
Experiments	15888456, 16930961, 15001550, 15604093, 21775429
Identification Methods	pull down, two hybrid, amplified luminescent proximity homogeneous assay
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045893 - positive regulation of DNA-templated transcription GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 Hs			1 1441
+	Hs
		740535 PPARG_HUMAN (13-441): 3.64e-114: 346: 57.28		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		992422 PPARA_HUMAN (15-441): 4.62e-112: 339: 64.72		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		587177 RXRA_HUMAN (4-438): 9.66e-111: 335: 24.77		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		874384 NR1H2_HUMAN (3-437): 8.44e-107: 325: 24.94		NCOA1_HUMAN (1-1441): 3.28e-155: 509: 100.00
+	Hs
		126103 RXRA_HUMAN (4-438): 9.66e-111: 335: 24.77		BMAL1_HUMAN (1-539): 2.88e-105: 350: 16.16
+	Hs
		975487 PPARD_HUMAN (1-441): 5.15e-125: 371: 100.00		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		740635 PPARG_HUMAN (13-441): 3.64e-114: 346: 57.28		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		992458 PPARA_HUMAN (15-441): 4.62e-112: 339: 64.72		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		587212 RXRA_HUMAN (4-438): 9.66e-111: 335: 24.77		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		490089 COT1_HUMAN (3-437): 6.99e-107: 324: 23.08		AHR_HUMAN (2-833): 8.86e-80: 284: 13.86
+	Hs
		181498 RXRA_HUMAN (4-438): 9.66e-111: 335: 24.77		CLOCK_HUMAN (5-833): 1.42e-75: 271: 14.15
+	Hs
		874407 NR1H2_HUMAN (3-437): 8.44e-107: 325: 24.94		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		490120 COT1_HUMAN (3-437): 6.99e-107: 324: 23.08		NCOA3_HUMAN (1-1343): 5.25e-75: 277: 24.33
+	Hs
		975430 PPARD_HUMAN (1-441): 5.15e-125: 371: 100.00		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		740529 PPARG_HUMAN (13-441): 3.64e-114: 346: 57.28		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Mm
		740717 PPARG_MOUSE (15-441): 1.6e-113: 344: 56.61		NCOA2_MOUSE (496-1439): 7.26e-12: 72.6: 10.82
+	Hs
		992420 PPARA_HUMAN (15-441): 4.62e-112: 339: 64.72		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587173 RXRA_HUMAN (4-438): 9.66e-111: 335: 24.77		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43
+	Hs
		587195 RXRA_HUMAN (4-438): 9.66e-111: 335: 24.77		NPAS2_HUMAN (29-210): 2.08e-09: 64.3: 29.73
+	Hs
		490101 COT1_HUMAN (3-437): 6.99e-107: 324: 23.08		NCOA2_HUMAN (496-1439): 2.6e-11: 70.7: 9.43