HitPredict

Interactor 1: TF65 (Q04207)
Transcription factor p65 (Nuclear factor NF-kappa-B p65 subunit) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)
Gene: Rela

Interactor 2: SIR1 (Q923E4)
NAD-dependent protein deacetylase sirtuin-1 (EC 2.3.1.286) (NAD-dependent protein deacylase sirtuin-1) (EC 2.3.1.-) (Regulatory protein SIR2 homolog 1) (SIR2-like protein 1) (SIR2alpha) (Sir2) (mSIR2a) [Cleaved into: SirtT1 75 kDa fragment (75SirT1)]
Gene: Sirt1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

The method score is based on:

Property	Details
Experiments	21454709, 37200907
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

The annotation score is based on:

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000785 - chromatin GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0005634 - nucleus GO:0005737 - cytoplasm and 9 others more... GO:0005829 - cytosol GO:0008284 - positive regulation of cell population proliferation GO:0019899 - enzyme binding GO:0032868 - response to insulin GO:0032991 - protein-containing complex GO:0043066 - negative regulation of apoptotic process GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0070301 - cellular response to hydrogen peroxide GO:0071356 - cellular response to tumor necrosis factor
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1	549
Mm

1	737

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024