HitPredict

Interactor 1: TLE3 (Q04726)
Transducin-like enhancer protein 3 (Enhancer of split groucho-like protein 3) (ESG3)
Gene: TLE3

Interactor 2: AUTS2 (Q8WXX7)
Autism susceptibility gene 2 protein
Gene: AUTS2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	25519132, 37689310
Identification Methods	affinity chromatography technology, proximity labelling technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 772 Hs			1 1259
+	Hs
		980878 TLE3_HUMAN (1-772): 0: 583: 100.00		FBSL_HUMAN (79-931): 1.69e-39: 162: 35.03
+	Hs
		980876 TLE3_HUMAN (1-772): 0: 583: 100.00		FBRS_HUMAN (563-885): 1.05e-30: 129: 41.54
+	Hs
		980896 TLE3_HUMAN (1-772): 0: 583: 100.00		RERE_HUMAN (10-900): 6.62e-13: 75.9: 9.42
+	Hs
		152632 TLE3_HUMAN (1-772): 0: 583: 100.00		KMT2D_HUMAN (75-890): 1.52e-10: 68.4: 12.98
+	Hs
		980847 TLE3_HUMAN (1-772): 0: 583: 100.00		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Hs
		980825 TLE3_HUMAN (1-772): 0: 583: 100.00		TITIN_HUMAN (60-591): 1.15e-09: 65.3: 11.92
+	Hs
		980660 TLE1_HUMAN (1-772): 0: 538: 77.42		RERE_HUMAN (10-900): 6.62e-13: 75.9: 9.42
+	Hs
		903392 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		AUTS2_HUMAN (1-1259): 1.57e-142: 466: 100.00
+	Hs
		903374 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		KMT2C_HUMAN (430-1258): 3.63e-13: 77: 9.23
+	Hs
		903229 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		NCOA6_HUMAN (63-1250): 4.76e-13: 76.3: 10.27
+	Hs
		903576 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		RERE_HUMAN (10-900): 6.62e-13: 75.9: 9.42
+	Hs
		152663 WDR5B_HUMAN (284-559): 4.84e-33: 132: 8.80		KMT2D_HUMAN (75-890): 1.52e-10: 68.4: 12.98
+	Hs
		152622 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		KMT2D_HUMAN (75-890): 1.52e-10: 68.4: 12.98
+	Hs
		903450 WDR5_HUMAN (284-560): 2.42e-32: 130: 9.12		CIC_HUMAN (124-1255): 2.4e-10: 67.4: 9.34
+	Mm
		903669 WDR5_MOUSE (284-560): 2.42e-32: 130: 9.12		KMT2C_MOUSE (323-1230): 5.99e-10: 66.3: 9.64
+	Hs
		1056932 SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52		MDC1_HUMAN (700-1257): 7.36e-10: 65.9: 8.20
+	Hs
		1264784 SNR40_HUMAN (509-677): 5.35e-09: 60.8: 26.52		TITIN_HUMAN (60-591): 1.15e-09: 65.3: 11.92