HitPredict

Interactor 1: TLE4 (Q04727)
Transducin-like enhancer protein 4 (Grg-4) (Groucho-related protein 4)
Gene: TLE4

Interactor 2: ISX (Q2M1V0)
Intestine-specific homeobox (RAX-like homeobox)
Gene: ISX

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	33961781, 35140242
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 773 Hs			1 245
+	Hs
		980618 TLE1_HUMAN (8-773): 0: 580: 86.27		ISX_HUMAN (1-245): 1.19e-56: 182: 100.00
+	Mm
		623700 TLE4_MOUSE (1-773): 0: 623: 99.61		PAX3_MOUSE (56-245): 5.02e-33: 126: 27.37
+	Hs
		620144 TLE4_HUMAN (1-773): 0: 622: 100.00		PAX7_HUMAN (65-245): 1.59e-30: 120: 30.06
+	Hs
		641379 TLE4_HUMAN (1-773): 0: 622: 100.00		PAX6_HUMAN (36-236): 2.07e-29: 115: 25.37
+	Hs
		980762 TLE3_HUMAN (8-773): 0: 539: 80.90		ISX_HUMAN (1-245): 1.19e-56: 182: 100.00
+	Hs
		980956 TLE4_HUMAN (1-773): 0: 622: 100.00		VSX1_HUMAN (72-142): 4.5e-18: 84: 59.16
+	Hs
		839732 TLE1_HUMAN (8-773): 0: 580: 86.27		LHX2_HUMAN (23-225): 2.91e-32: 123: 22.17
+	Hs
		620142 TLE1_HUMAN (8-773): 0: 580: 86.27		PAX7_HUMAN (65-245): 1.59e-30: 120: 30.06
+	Hs
		641377 TLE1_HUMAN (8-773): 0: 580: 86.27		PAX6_HUMAN (36-236): 2.07e-29: 115: 25.37
+	Hs
		980659 TLE1_HUMAN (8-773): 0: 580: 86.27		VSX1_HUMAN (72-142): 4.5e-18: 84: 59.16
+	Hs
		620143 TLE3_HUMAN (8-773): 0: 539: 80.90		PAX7_HUMAN (65-245): 1.59e-30: 120: 30.06
+	Hs
		641378 TLE3_HUMAN (8-773): 0: 539: 80.90		PAX6_HUMAN (36-236): 2.07e-29: 115: 25.37
+	Hs
		980756 TLE3_HUMAN (8-773): 0: 539: 80.90		SIX1_HUMAN (8-235): 5.65e-30: 115: 14.52
+	Hs
		980893 TLE3_HUMAN (8-773): 0: 539: 80.90		VSX1_HUMAN (72-142): 4.5e-18: 84: 59.16
+	Dm
		185801 GROU_DROME (8-773): 1.23e-144: 443: 59.14		PAX6_DROME (54-145): 1.24e-17: 83.6: 45.83
+	Dm
		558365 GROU_DROME (8-773): 1.23e-144: 443: 59.14		GSC_DROME (80-142): 2.89e-17: 82: 60.32
+	Ce
		137665 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		UNC4_CAEEL (2-224): 1.86e-35: 128: 25.76
+	Ce
		137685 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		HM30_CAEEL (31-223): 2.46e-32: 119: 21.54
+	Ce
		137669 UNC37_CAEEL (24-773): 5.04e-95: 310: 36.86		HM09_CAEEL (44-154): 2.11e-30: 111: 27.93
+	Hs
		620146 TLE5_HUMAN (8-205): 3.48e-94: 293: 67.68		PAX7_HUMAN (65-245): 1.59e-30: 120: 30.06