HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	29426014
Identification Methods	two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 875 Hs			1 1128
+	Hs
		983102 UBE3A_HUMAN (1-875): 0: 1058: 100.00		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		983223 UBE3A_HUMAN (1-875): 0: 1058: 100.00		BARD1_HUMAN (676-1036): 1.54e-45: 179: 16.83
+	Hs
		808118 NEDD4_HUMAN (46-873): 0: 622: 21.49		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		276173 UBE3A_HUMAN (1-875): 0: 1058: 100.00		PSD10_HUMAN (988-1128): 3e-43: 159: 16.77
+	Hs
		125441 WWP2_HUMAN (291-873): 0: 589: 24.72		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		1043731 ITCH_HUMAN (325-873): 0: 579: 24.78		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		983196 UBE3A_HUMAN (1-875): 0: 1058: 100.00		ANR49_HUMAN (906-1000): 8.85e-19: 88.7: 30.53
+	Hs
		808103 NEDD4_HUMAN (46-873): 0: 622: 21.49		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		125654 WWP2_HUMAN (291-873): 0: 589: 24.72		ASPP1_HUMAN (1-1128): 4.45e-135: 439: 45.38
+	Mm
		966330 ITCH_MOUSE (325-873): 0: 576: 25.04		NOTC1_MOUSE (608-1051): 1.86e-45: 182: 14.09
+	Hs
		125054 WWP2_HUMAN (291-873): 0: 589: 24.72		PSD10_HUMAN (988-1128): 3e-43: 159: 16.77
+	Hs
		125583 WWP2_HUMAN (291-873): 0: 589: 24.72		ANR44_HUMAN (962-1128): 1.48e-36: 151: 19.16
+	Hs
		1305975 HERC5_HUMAN (153-873): 1.77e-175: 536: 23.20		BARD1_HUMAN (676-1036): 1.54e-45: 179: 16.83
+	Hs
		1121777 HERC4_HUMAN (157-875): 3.32e-179: 547: 27.46		ANR39_HUMAN (873-1036): 4.49e-22: 96.8: 23.12
+	Hs
		1336115 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		ANR50_HUMAN (836-995): 6.95e-17: 88.7: 16.88
+	Hs
		1336100 SMUF1_HUMAN (405-872): 1.32e-175: 528: 27.04		DAPLE_HUMAN (33-349): 6.45e-16: 85.6: 16.36
+	Mm
		1186482 HUWE1_MOUSE (523-874): 7.59e-53: 203: 33.97		KANK2_MOUSE (323-1049): 1.95e-66: 243: 16.35
+	Hs
		1192213 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		Q9H4D1_HUMAN (573-1024): 4.3e-26: 117: 11.58
+	Hs
		883550 HUWE1_HUMAN (523-874): 5.96e-53: 203: 33.97		RIPK4_HUMAN (863-1024): 1.42e-25: 116: 19.63
+	Hs
		1072718 UBE3C_HUMAN (453-872): 2.23e-52: 200: 32.27		Q9H4D1_HUMAN (573-1024): 4.3e-26: 117: 11.58