HitPredict

Interactor 1: UBE3A (Q05086)
Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54)
Gene: UBE3A

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.920

The method score is based on:

Property Details
Experiments 29426014, 10983987, 35358511, 36827983
Identification Methods two hybrid, pull down, affinity chromatography technology, x-ray crystallography, two hybrid prey pooling approach, two hybrid array
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains HECT~ubiquitin
Common GO terms GO:0000502 - proteasome complex
GO:0005829 - cytosol
GO:0006511 - ubiquitin-dependent protein catabolic process
GO:0031398 - positive regulation of protein ubiquitination
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 875
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024