HitPredict

Interactor 1: DYN1 (Q05193)
Dynamin-1 (EC 3.6.5.5) (Dynamin) (Dynamin I)
Gene: DNM1

Interactor 2: FAK2 (Q14289)
Protein-tyrosine kinase 2-beta (EC 2.7.10.2) (Calcium-dependent tyrosine kinase) (CADTK) (Calcium-regulated non-receptor proline-rich tyrosine kinase) (Cell adhesion kinase beta) (CAK-beta) (CAKB) (Focal adhesion kinase 2) (FADK 2) (Proline-rich tyrosine kinase 2) (Related adhesion focal tyrosine kinase) (RAFTK)
Gene: PTK2B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19380485
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm GO:0098793 - presynapse GO:0098978 - glutamatergic synapse
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 864 Hs			1 1009
+	Hs
		983371 DYN1_HUMAN (1-864): 0: 1087: 100.00		FAK1_HUMAN (39-1000): 0: 846: 44.25
+	Hs
		840673 DYN2_HUMAN (1-860): 0: 1021: 78.91		FAK1_HUMAN (39-1000): 0: 846: 44.25
+	Mm
		710125 DYN2_MOUSE (1-860): 0: 1022: 79.13		FAK1_MOUSE (39-1000): 0: 840: 44.15
+	Hs
		337437 DYN1_HUMAN (1-864): 0: 1087: 100.00		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		522926 DYN1_HUMAN (1-864): 0: 1087: 100.00		SRC_HUMAN (288-695): 5.62e-117: 371: 27.74
+	Hs
		337399 DYN2_HUMAN (1-860): 0: 1021: 78.91		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		383697 DYN2_HUMAN (1-860): 0: 1021: 78.91		ERBB2_HUMAN (286-908): 2.13e-124: 411: 21.96
+	Hs
		337597 DYN3_HUMAN (1-860): 0: 998: 78.12		ABL1_HUMAN (264-885): 2.55e-133: 432: 23.56
+	Hs
		411645 DYN2_HUMAN (1-860): 0: 1021: 78.91		LCK_HUMAN (208-694): 1.45e-123: 387: 27.18
+	Hs
		522862 DYN2_HUMAN (1-860): 0: 1021: 78.91		SRC_HUMAN (288-695): 5.62e-117: 371: 27.74
+	Hs
		412090 DYN2_HUMAN (1-860): 0: 1021: 78.91		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		442794 DYN2_HUMAN (1-860): 0: 1021: 78.91		HCK_HUMAN (286-694): 3.05e-116: 369: 30.10
+	Hs
		507913 DYN2_HUMAN (1-860): 0: 1021: 78.91		FGFR1_HUMAN (360-728): 4.75e-110: 362: 29.08
+	Hs
		609215 DYN2_HUMAN (1-860): 0: 1021: 78.91		FGFR3_HUMAN (351-683): 4.17e-109: 359: 31.39
+	Hs
		412411 DYN3_HUMAN (1-860): 0: 998: 78.12		FYN_HUMAN (288-695): 1.25e-116: 370: 29.68
+	Hs
		508270 DYN3_HUMAN (1-860): 0: 998: 78.12		FGFR1_HUMAN (360-728): 4.75e-110: 362: 29.08
+	Hs
		609615 DYN3_HUMAN (1-860): 0: 998: 78.12		FGFR3_HUMAN (351-683): 4.17e-109: 359: 31.39