HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	11158308
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	C1_1~Pkinase, PB1~PB1, PB1~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004672 - protein kinase activity GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0007165 - signal transduction GO:0046872 - metal ion binding and 1 others more... GO:0106310 - protein serine kinase activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 592 Hs			1 448
+	Hs
		783996 KPCI_HUMAN (1-592): 0: 654: 69.87		MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00
+	Mm
		1143288 KPCI_MOUSE (1-592): 0: 655: 69.70		MP2K5_MOUSE (1-448): 1.04e-151: 440: 97.77
+	Hs
		682169 KPCZ_HUMAN (1-592): 0: 688: 100.00		AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86
+	Hs
		983943 KPCZ_HUMAN (1-592): 0: 688: 100.00		AKT3_HUMAN (111-444): 6.73e-124: 370: 20.34
+	Hs
		681802 KPCZ_HUMAN (1-592): 0: 688: 100.00		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Mm
		682107 KPCZ_MOUSE (1-592): 0: 681: 95.61		AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57
+	Hs
		784032 KPCI_HUMAN (1-592): 0: 654: 69.87		MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59
+	Hs
		983953 KPCZ_HUMAN (1-592): 0: 688: 100.00		STK24_HUMAN (163-421): 2.25e-106: 324: 35.61
+	Hs
		983820 KPCZ_HUMAN (1-592): 0: 688: 100.00		PAK1_HUMAN (94-420): 7.29e-104: 321: 28.11
+	Xl
		1193382 Q91569_XENLA (1-592): 0: 638: 68.45		Q804T2_XENLA (114-442): 1.06e-119: 367: 20.35
+	Rn
		448424 KPCZ_RAT (1-592): 0: 686: 95.95		MP2K1_RAT (139-448): 4.24e-102: 311: 40.29
+	Rn
		448421 KPCZ_RAT (1-592): 0: 686: 95.95		MP2K2_RAT (146-448): 4.13e-83: 263: 40.63
+	Hs
		800976 KPCZ_HUMAN (1-592): 0: 688: 100.00		MP2K4_HUMAN (164-448): 5.47e-63: 210: 41.78
+	Hs
		681803 KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Hs
		682218 AKT2_HUMAN (148-582): 5.85e-155: 455: 36.12		AKT3_HUMAN (111-444): 6.73e-124: 370: 20.34
+	Hs
		681681 AKT2_HUMAN (148-582): 5.85e-155: 455: 36.12		AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82
+	Mm
		682096 AKT1_MOUSE (172-582): 4.54e-154: 452: 36.39		AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57
+	Hs
		623868 KPCL_HUMAN (6-585): 0: 568: 33.49		MP2K3_HUMAN (158-418): 1.56e-66: 218: 45.09
+	Mm
		814027 KPCT_MOUSE (14-583): 1.86e-178: 523: 31.46		MP2K4_MOUSE (164-448): 1.06e-62: 209: 41.45
+	Mm
		969033 KPCT_MOUSE (14-583): 1.86e-178: 523: 31.46		MP2K7_MOUSE (160-422): 2.42e-47: 172: 38.27