HitPredict

Interactor 1: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Interactor 2: TRI41 (Q8WV44)
E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41)
Gene: TRIM41

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	28514442, 33961781, 17893151
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 592 Hs			1 630
+	Hs
		984519 KPCD_HUMAN (85-585): 1.92e-177: 519: 36.26		TRI41_HUMAN (1-630): 2.96e-166: 491: 100.00
+	Hs
		584935 KPCZ_HUMAN (1-592): 0: 688: 100.00		RO52_HUMAN (7-141): 1.35e-20: 97.4: 21.53
+	Hs
		983816 KPCZ_HUMAN (1-592): 0: 688: 100.00		TRI26_HUMAN (7-217): 4.05e-19: 93.1: 16.90
+	Hs
		682017 AKT1_HUMAN (172-582): 1.55e-153: 451: 36.39		TRI15_HUMAN (136-628): 6.8e-105: 327: 26.69
+	Hs
		408652 KPCB_HUMAN (85-187): 1.04e-21: 101: 27.18		TRI41_HUMAN (1-630): 2.96e-166: 491: 100.00
+	Hs
		566440 KPCA_HUMAN (101-181): 1.39e-16: 85.3: 29.63		TRI41_HUMAN (1-630): 2.96e-166: 491: 100.00
+	Hs
		850697 KS6A3_HUMAN (168-539): 2.67e-105: 335: 20.47		TRI11_HUMAN (1-130): 1.56e-22: 103: 26.81
+	Hs
		397179 KPCG_HUMAN (116-180): 1.87e-10: 65.9: 36.92		TRIM5_HUMAN (6-150): 3.22e-22: 102: 19.46