HitPredict

Interactor 1: SRS11 (Q05519)
Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)
Gene: SRSF11

Interactor 2: RNPS1 (Q15287)
RNA-binding protein with serine-rich domain 1 (SR-related protein LDC2)
Gene: RNPS1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.867

Property	Details
Experiments	14729963, 33961781, 17353931
Identification Methods	affinity chromatography technology, two hybrid, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	RRM_1~RRM_1
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0008380 - RNA splicing GO:0016607 - nuclear speck
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 484 Hs			1 305
+	Hs
		984135 SRS11_HUMAN (1-484): 6.69e-53: 187: 100.00		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		1246388 THOC2_HUMAN (224-482): 1.34e-35: 143: 22.66		PPIE_HUMAN (159-297): 4.41e-33: 125: 17.73
+	Hs
		1037806 PRP4K_HUMAN (209-451): 5.94e-11: 67.2: 19.71		RNPS1_HUMAN (1-234): 2e-34: 128: 100.00
+	Hs
		1037928 PRP4K_HUMAN (209-451): 5.94e-11: 67.2: 19.71		RBM8A_HUMAN (95-239): 7.02e-31: 115: 21.38
+	Hs
		853883 PRP4K_HUMAN (209-451): 5.94e-11: 67.2: 19.71		NCBP2_HUMAN (128-271): 1.08e-30: 114: 18.06
+	Hs
		516609 TITIN_HUMAN (33-483): 2.57e-10: 65.4: 8.99		PABP1_HUMAN (65-252): 1.33e-21: 96.9: 16.32
+	Hs
		1031405 TITIN_HUMAN (33-483): 2.57e-10: 65.4: 8.99		PABP4_HUMAN (153-248): 4.98e-19: 89.2: 27.08
+	Hs
		965152 ANK2_HUMAN (209-479): 7.77e-09: 60.7: 19.57		PABP3_HUMAN (153-248): 4.53e-17: 83.4: 26.04