Protein: GBB4
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)

Gene: GBB4, GNB4
Organism: Homo sapiens
Interactions: 133
UniProt ID: Q9HAV0

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005765 - lysosomal membrane
GO:0005829 - cytosol
GO:0005834 - heterotrimeric G-protein complex
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476036

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

5

20

Small-scale

0.714

High

948081

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

5

20

Small-scale

0.713

High

893560

GBG4

4

20

Small-scale

0.697

High

992433

GBG3

4

20

Small-scale

0.697

High

418741

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

4

20

Small-scale

0.696

High

989876

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

4

20

Small-scale

0.696

High

992453

GBG5

4

20

Small-scale

0.690

High

893582

GBG10

3

20

Small-scale

0.656

High

1437756

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

3

20

Small-scale

0.656

High

989795

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

3

20

High-throughput

0.656

High

243474

GBG7

3

20

Small-scale

0.647

High

869792

MTR1A
Melatonin receptor type 1A

2

8

Small-scale

0.634

High

1030297

GALK2
N-acetylgalactosamine kinase

2

3

High-throughput

0.628

High

992421

GBG1
Guanine nucleotide-binding protein G(T) subunit gamma-T1

2

20

Small-scale

0.619

High

880967

MTR1B
Melatonin receptor type 1B

2

7

Small-scale

0.611

High

478728

HXB5
Homeobox protein Hox-B5

2

2

High-throughput

0.611

High

1437751

GBG13

2

6

Small-scale

0.602

High

616809

SDC1
Syndecan-1

2

0

High-throughput

0.602

High

983582

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

15

High-throughput

0.601

High

396978

ESR1
Estrogen receptor

2

20

Small-scale

0.594

High

1095058

DUS4
Dual specificity protein phosphatase 4

2

2

High-throughput

0.571

High

318096

PKHG5
Pleckstrin homology domain-containing family G member 5

1

17

High-throughput

0.536

High

1057662

CDK18
Cyclin-dependent kinase 18

1

5

High-throughput

0.536

High

1091842

TP4A2
Protein tyrosine phosphatase type IVA 2

1

4

High-throughput

0.536

High

1125929

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

20

High-throughput

0.536

High

1157071

NTRK3
NT-3 growth factor receptor

1

12

High-throughput

0.536

High

1329976

GP161
G-protein coupled receptor 161

1

6

High-throughput

0.536

High

1402971

CP2S1
Cytochrome P450 2S1

1

1

High-throughput

0.536

High

1437757

FZD10
Frizzled-10

1

2

High-throughput

0.536

High

562404

LAMP2
Lysosome-associated membrane glycoprotein 2

1

1

High-throughput

0.515

High

1437760

SHLB1
Endophilin-B1

1

3

High-throughput

0.515

High

508656

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

High-throughput

0.501

High

951857

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

964194

GBG11

1

20

Small-scale

0.501

High

1437752

GBG12

1

20

Small-scale

0.501

High

937112

CASP6
Caspase-6

1

0

High-throughput

0.493

High

873885

KCNJ5
G protein-activated inward rectifier potassium channel 4

1

2

High-throughput

0.489

High

1219056

RSBN1
Lysine-specific demethylase 9

1

2

High-throughput

0.489

High

1435991

PACC1
Proton-activated chloride channel

1

1

High-throughput

0.489

High

158716

GBGT2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2

1

20

Small-scale

0.481

High

130854

DFFA
DNA fragmentation factor subunit alpha

1

1

High-throughput

0.479

High

157870

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

166419

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

1

High-throughput

0.479

High

173391

XPO1
Exportin-1

1

10

High-throughput

0.479

High

178399

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

223342

PRC1
Protein regulator of cytokinesis 1

1

5

High-throughput

0.479

High

242974

PRKN
E3 ubiquitin-protein ligase parkin

1

10

High-throughput

0.479

High

294347

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

331336

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

343280

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.479

High

373187

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

458490

ADRB2
Beta-2 adrenergic receptor

1

5

High-throughput

0.479

High

459337

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

466469

RHOC
Rho-related GTP-binding protein RhoC

1

12

High-throughput

0.479

High

564388

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.479

High

581299

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

607116

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

862471

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

889371

RGS6
Regulator of G-protein signaling 6

1

13

Small-scale

0.479

High

910205

RND2
Rho-related GTP-binding protein RhoN

1

12

High-throughput

0.479

High

930055

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

8

High-throughput

0.479

High

953682

RAC3
Ras-related C3 botulinum toxin substrate 3

1

11

High-throughput

0.479

High

955615

CDC42
Cell division control protein 42 homolog

1

11

High-throughput

0.479

High

959257

ABCE1
ATP-binding cassette sub-family E member 1

1

2

High-throughput

0.479

High

962506

RHOA
Transforming protein RhoA

1

12

High-throughput

0.479

High

978315

RHOB
Rho-related GTP-binding protein RhoB

1

12

High-throughput

0.479

High

988722

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.479

High

998825

H31
Histone H3.1

1

8

High-throughput

0.479

High

1015800

RHOG
Rho-related GTP-binding protein RhoG

1

10

High-throughput

0.479

High

1086317

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

1103660

PHLP
Phosducin-like protein

1

15

Small-scale

0.479

High

1115073

CUL4A
Cullin-4A

1

20

Small-scale

0.479

High

1130024

KCTD2
BTB/POZ domain-containing protein KCTD2

1

14

Small-scale

0.479

High

1137162

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

16

High-throughput

0.479

High

1140885

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

1151883

RHOH
Rho-related GTP-binding protein RhoH

1

13

High-throughput

0.479

High

1197567

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

6

High-throughput

0.479

High

1247932

ANR12
Ankyrin repeat domain-containing protein 12

1

9

High-throughput

0.479

High

1255603

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.479

High

1277680

RD3
Protein RD3

1

1

High-throughput

0.479

High

1309497

CEP97
Centrosomal protein of 97 kDa

1

5

Small-scale

0.479

High

1311974

SKA3
Spindle and kinetochore-associated protein 3

1

1

Small-scale

0.479

High

1328676

KCD17
BTB/POZ domain-containing protein KCTD17

1

14

Small-scale

0.479

High

1352762

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

4

High-throughput

0.479

High

1397444

CI072
Guanine nucleotide exchange factor C9orf72

1

3

High-throughput

0.479

High

1404671

PFD5
Prefoldin subunit 5

1

11

High-throughput

0.479

High

1417478

FACD2
Fanconi anemia group D2 protein

1

3

High-throughput

0.479

High

1433079

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

1433515

RHOJ
Rho-related GTP-binding protein RhoJ

1

12

High-throughput

0.479

High

1436485

ECT2
Protein ECT2

1

17

High-throughput

0.479

High

1437743

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

1437744

ANLN
Anillin

1

7

High-throughput

0.479

High

1437748

KCTD5
BTB/POZ domain-containing protein KCTD5

1

14

Small-scale

0.479

High

1437753

HDAC6
Protein deacetylase HDAC6

1

10

High-throughput

0.479

High

1437754

UBQL2
Ubiquilin-2

1

3

High-throughput

0.479

High

1437755

FKBPL
FK506-binding protein-like

1

19

High-throughput

0.479

High

1437758

LIMC1
LIM and calponin homology domains-containing protein 1

1

7

High-throughput

0.479

High

1437759

NUDC
Nuclear migration protein nudC

1

16

High-throughput

0.479

High

1437762

ARI1
E3 ubiquitin-protein ligase ARIH1

1

9

High-throughput

0.479

High

1437763

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

3

High-throughput

0.479

High

472352

CFAH
Complement factor H

1

0

Small-scale

0.458

High

621525

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

1437745

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1437746

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

1416915

KLF16
Krueppel-like factor 16

1

2

High-throughput

0.457

High

337649

GNAS3
Neuroendocrine secretory protein 55

1

2

High-throughput

0.445

High

411062

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

10

High-throughput

0.445

High

765904

BMI1
Polycomb complex protein BMI-1

1

12

High-throughput

0.445

High

1033945

SC6A3
Sodium-dependent dopamine transporter

1

2

High-throughput

0.445

High

1119310

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

1329623

CD177
CD177 antigen

1

3

Small-scale

0.445

High

1341099

INADL
InaD-like protein

1

6

High-throughput

0.445

High

1359501

CTL1
Choline transporter-like protein 1

1

2

High-throughput

0.445

High

667463

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

7

Small-scale

0.437

High

1384535

Q96BE0
Heat shock cognate 71 kDa protein

1

17

High-throughput

0.437

High

1390944

TSN17
Tetraspanin-17

1

2

High-throughput

0.437

High

1402444

CCNL2
Cyclin-L2

1

2

High-throughput

0.437

High

1437742

Q9HAV2
Heat shock transcription factor 1

1

3

High-throughput

0.437

High

1437747

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.437

High

1437749

MTCH1
Mitochondrial carrier homolog 1

1

6

High-throughput

0.437

High

1437761

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

20

High-throughput

0.437

High

211183

CTR4
Cationic amino acid transporter 4

1

1

High-throughput

0.407

High

552397

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.407

High

1131618

MFS10
Major facilitator superfamily domain-containing protein 10

1

3

High-throughput

0.407

High

1420717

ZDHC5
Palmitoyltransferase ZDHHC5

1

5

High-throughput

0.407

High

1032050

TFAP4
Transcription factor AP-4

1

0

High-throughput

0.279

Low

1244087

CXB7
Gap junction beta-7 protein

1

0

High-throughput

0.279

Low

1433707

SEHL2
Serine hydrolase-like protein 2

1

0

High-throughput

0.279

Low

1437750

KCND2
A-type voltage-gated potassium channel KCND2

1

0

High-throughput

0.279

Low

67200

LRIQ3
Leucine-rich repeat and IQ domain-containing protein 3

1

0

High-throughput

0.249

Low

163473

MEIS2
Homeobox protein Meis2

1

0

High-throughput

0.249

Low

1338679

T185A
Transmembrane protein 185A

1

0

High-throughput

0.249

Low

1359986

MB3L1
Methyl-CpG-binding domain protein 3-like 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025