HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: DDR1 (Q08345)
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) (EC 2.7.10.1) (CD167 antigen-like family member A) (Cell adhesion kinase) (Discoidin receptor tyrosine kinase) (HGK2) (Mammary carcinoma kinase 10) (MCK-10) (Protein-tyrosine kinase 3A) (Protein-tyrosine kinase RTK-6) (TRK E) (Tyrosine kinase DDR) (Tyrosine-protein kinase CAK) (CD antigen CD167a)
Gene: DDR1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.706

Property	Details
Experiments	22057045, 16337946
Identification Methods	pull down, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, coimmunoprecipitation
Interaction Type	association, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 913
+	Hs
		522931 PTN11_HUMAN (1-593): 0: 581: 100.00		SRC_HUMAN (361-912): 1.28e-125: 391: 23.60
+	Hs
		609260 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR3_HUMAN (551-905): 1.32e-110: 360: 32.16
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (583-905): 4.2e-109: 357: 34.05
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (540-905): 6.78e-109: 356: 32.52
+	Hs
		607949 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR4_HUMAN (554-910): 8.48e-107: 350: 33.87
+	Mm
		546284 PTN11_MOUSE (1-593): 0: 580: 99.49		NTRK2_MOUSE (604-906): 6.4e-105: 346: 43.89
+	Hs
		985963 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK2_HUMAN (604-906): 1.75e-104: 345: 43.89
+	Rn
		783507 PTN11_RAT (1-593): 0: 578: 98.99		NTRK2_RAT (604-906): 6.67e-105: 345: 43.89
+	Hs
		985962 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK3_HUMAN (607-905): 4.06e-67: 242: 43.63
+	Hs
		384697 PTN11_HUMAN (1-593): 0: 581: 100.00		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Hs
		411363 PTN11_HUMAN (1-593): 0: 581: 100.00		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		445845 PTN11_HUMAN (1-593): 0: 581: 100.00		ROS1_HUMAN (571-902): 5.2e-52: 201: 35.38
+	Hs
		435620 PTN11_HUMAN (1-593): 0: 581: 100.00		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22
+	Rn
		783510 PTN11_RAT (1-593): 0: 578: 98.99		T2CB11_RAT (600-908): 1.72e-51: 199: 36.25
+	Hs
		968364 PTN11_HUMAN (1-593): 0: 581: 100.00		ROR2_HUMAN (608-905): 1.57e-50: 194: 38.26
+	Hs
		384330 PTN6_HUMAN (6-593): 0: 531: 55.27		NTRK1_HUMAN (607-902): 1.43e-66: 240: 45.27
+	Mm
		337619 PTN11_MOUSE (1-593): 0: 580: 99.49		ABL1_MOUSE (604-903): 6.09e-49: 190: 37.67
+	Hs
		411311 PTN6_HUMAN (6-593): 0: 531: 55.27		INSR_HUMAN (600-908): 7.71e-53: 202: 37.42
+	Hs
		445827 PTN6_HUMAN (6-593): 0: 531: 55.27		ROS1_HUMAN (571-902): 5.2e-52: 201: 35.38
+	Hs
		435549 PTN6_HUMAN (6-593): 0: 531: 55.27		IGF1R_HUMAN (600-908): 4.51e-51: 197: 37.22