Protein: HSPB2
Heat shock protein beta-2 (HspB2) (DMPK-binding protein) (MKBP) (Heat shock protein family B member 2)

Gene: HSPB2
Organism: Homo sapiens
Interactions: 148
UniProt ID: Q16082

Gene Ontology (top 5):
GO:0005212 - structural constituent of eye lens
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006986 - response to unfolded protein

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

384675

CRYAB
Alpha-crystallin B chain

5

15

Small-scale

0.929

High

1156344

HSPB8
Heat shock protein beta-8

2

16

Small-scale

0.817

High

1156289

HSPB2
Heat shock protein beta-2

2

16

Small-scale

0.809

High

384421

CRYAA
Alpha-crystallin A chain

1

15

Small-scale

0.713

High

415596

HSPB1
Heat shock protein beta-1

1

16

High-throughput

0.691

High

347726

BAG3
BAG family molecular chaperone regulator 3

3

9

High-throughput

0.665

High

1125341

FLNC
Filamin-C

1

18

High-throughput

0.656

High

1066214

DMPK
Myotonin-protein kinase

2

6

Small-scale

0.633

High

1092295

HSPB3
Heat shock protein beta-3

1

17

Small-scale

0.618

High

290388

RFPL3
Ret finger protein-like 3

2

2

High-throughput

0.606

High

682034

RBTN1
Rhombotin-1

2

6

High-throughput

0.606

High

1120668

VEZF1
Vascular endothelial zinc finger 1

2

3

High-throughput

0.606

High

1156295

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

7

High-throughput

0.606

High

1156301

POGZ
Pogo transposable element with ZNF domain

2

3

High-throughput

0.606

High

1156309

LMO3
LIM domain only protein 3

2

6

High-throughput

0.606

High

1156323

BEX2
Protein BEX2

2

1

High-throughput

0.606

High

1156332

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

2

High-throughput

0.606

High

1156336

A1CF
APOBEC1 complementation factor

2

3

High-throughput

0.606

High

1156341

WWOX
WW domain-containing oxidoreductase

2

2

High-throughput

0.606

High

993591

UBC9
SUMO-conjugating enzyme UBC9

2

6

Small-scale

0.584

High

225006

TLX3
T-cell leukemia homeobox protein 3

2

0

High-throughput

0.580

High

604821

HXB9
Homeobox protein Hox-B9

2

0

High-throughput

0.580

High

1156317

CEP19
Centrosomal protein of 19 kDa

2

0

High-throughput

0.580

High

1120170

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

3

Small-scale

0.561

High

1156302

MISP
Mitotic interactor and substrate of PLK1

2

1

High-throughput

0.553

High

959589

MAX
Protein max

1

4

High-throughput

0.536

High

1156300

MCAF1
Activating transcription factor 7-interacting protein 1

1

3

High-throughput

0.536

High

1156318

BTBD9
BTB/POZ domain-containing protein 9

1

4

High-throughput

0.536

High

1156324

PCGF6
Polycomb group RING finger protein 6

1

5

High-throughput

0.536

High

1156327

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

5

High-throughput

0.536

High

1156334

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

2

High-throughput

0.536

High

1156345

YETS2
YEATS domain-containing protein 2

1

1

High-throughput

0.536

High

1156346

TRI33
E3 ubiquitin-protein ligase TRIM33

1

8

High-throughput

0.536

High

422168

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

1013393

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

1156305

MGAP
MAX gene-associated protein

1

0

High-throughput

0.513

High

1156314

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.513

High

1156331

CSR2B
Cysteine-rich protein 2-binding protein

1

0

High-throughput

0.513

High

1156337

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

185095

TELT
Telethonin

1

2

High-throughput

0.508

High

270365

WDR1
WD repeat-containing protein 1

1

3

High-throughput

0.508

High

380835

MYG
Myoglobin

1

2

High-throughput

0.508

High

402604

ALDOA
Fructose-bisphosphate aldolase A

1

4

High-throughput

0.508

High

408899

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.508

High

445657

KCRM
Creatine kinase M-type

1

3

High-throughput

0.508

High

445898

ENOA
Alpha-enolase

1

3

High-throughput

0.508

High

480801

LEG1
Galectin-1

1

4

High-throughput

0.508

High

538602

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

3

High-throughput

0.508

High

563013

MYH6
Myosin-6

1

10

High-throughput

0.508

High

569016

ENOB
Beta-enolase

1

3

High-throughput

0.508

High

703944

DUS1
Dual specificity protein phosphatase 1

1

6

High-throughput

0.508

High

786332

PGM1
Phosphoglucomutase-1

1

1

High-throughput

0.508

High

828656

MDHC
Malate dehydrogenase, cytoplasmic

1

4

High-throughput

0.508

High

834317

GARS
Glycine--tRNA ligase

1

1

High-throughput

0.508

High

938358

NH2L1
NHP2-like protein 1

1

1

High-throughput

0.508

High

952850

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.508

High

963514

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

High-throughput

0.508

High

985684

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.508

High

993191

ACTG
Actin, cytoplasmic 2

1

6

High-throughput

0.508

High

995619

ACTC
Actin, alpha cardiac muscle 1

1

6

High-throughput

0.508

High

996174

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.508

High

996461

ACTS
Actin, alpha skeletal muscle

1

6

High-throughput

0.508

High

1122978

FHL2
Four and a half LIM domains protein 2

1

5

High-throughput

0.508

High

1123641

DCTN1
Dynactin subunit 1

1

10

High-throughput

0.508

High

1124255

IF4A2
Eukaryotic initiation factor 4A-II

1

3

High-throughput

0.508

High

1133318

MYPC3
Myosin-binding protein C, cardiac-type

1

9

High-throughput

0.508

High

1153527

MLF2
Myeloid leukemia factor 2

1

3

High-throughput

0.508

High

1156308

CMYA5
Cardiomyopathy-associated protein 5

1

9

High-throughput

0.508

High

1156311

TITIN
Titin

1

12

High-throughput

0.508

High

1156313

RL36L
Ribosomal protein eL42-like

1

2

High-throughput

0.508

High

1156321

PKP2
Plakophilin-2

1

6

High-throughput

0.508

High

1156328

TXNIP
Thioredoxin-interacting protein

1

4

High-throughput

0.508

High

1156329

ZN335
Zinc finger protein 335

1

4

High-throughput

0.508

High

1156330

NT5D2
5'-nucleotidase domain-containing protein 2

1

2

High-throughput

0.508

High

1156333

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

2

High-throughput

0.508

High

1156339

BEX4
Protein BEX4

1

1

High-throughput

0.508

High

791416

SYUA
Alpha-synuclein

1

4

Small-scale

0.501

High

1156304

MAPK5
MAP kinase-activated protein kinase 5

1

8

Small-scale

0.501

High

1156315

C102A
Coiled-coil domain-containing protein 102A

1

11

High-throughput

0.489

High

133358

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.486

High

227092

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.486

High

253923

ABCC9
ATP-binding cassette sub-family C member 9

1

0

High-throughput

0.486

High

456236

CATD
Cathepsin D

1

0

High-throughput

0.486

High

866697

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.486

High

973454

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.486

High

1108786

ASAH1
Acid ceramidase

1

0

High-throughput

0.486

High

1156294

THMS2
Protein THEMIS2

1

0

High-throughput

0.486

High

1156322

THUM2
U6 snRNA

1

0

High-throughput

0.486

High

1156338

PARVA
Alpha-parvin

1

0

High-throughput

0.486

High

1156340

DDIT4
DNA damage-inducible transcript 4 protein

1

0

High-throughput

0.486

High

1156342

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.486

High

456053

CRGC
Gamma-crystallin C

1

13

Small-scale

0.481

High

622501

TNNI3
Troponin I, cardiac muscle

1

5

High-throughput

0.481

High

784790

VATE1
V-type proton ATPase subunit E 1

1

1

High-throughput

0.481

High

1013996

RL36A
Large ribosomal subunit protein eL42

1

2

High-throughput

0.481

High

1156325

UBL5
Ubiquitin-like protein 5

1

3

Small-scale

0.481

High

212727

TGFI1
Transforming growth factor beta-1-induced transcript 1 protein

1

8

Small-scale

0.479

High

520088

ANDR
Androgen receptor

1

5

Small-scale

0.479

High

553899

GRAA
Granzyme A

1

1

Small-scale

0.479

High

563822

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

Small-scale

0.479

High

1026401

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.479

High

1090664

TRAF2
TNF receptor-associated factor 2

1

3

Small-scale

0.479

High

1156343

DAXX
Death domain-associated protein 6

1

1

Small-scale

0.479

High

1156347

TRAF6
TNF receptor-associated factor 6

1

5

Small-scale

0.479

High

161136

ABCD4
Lysosomal cobalamin transporter ABCD4

1

1

High-throughput

0.464

High

360424

COX2
Cytochrome c oxidase subunit 2

1

1

High-throughput

0.464

High

369677

A2MG
Alpha-2-macroglobulin

1

3

High-throughput

0.464

High

423910

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.464

High

680369

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

2

High-throughput

0.464

High

842208

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

1

High-throughput

0.464

High

928837

MYOM2
Myomesin-2

1

9

High-throughput

0.464

High

935875

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.464

High

1156307

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

1

High-throughput

0.464

High

1156310

AGA11
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 11

1

8

High-throughput

0.464

High

1156312

RYR2
Ryanodine receptor 2

1

1

High-throughput

0.464

High

445555

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.458

High

61032

A2VCT2
2-oxoglutarate dehydrogenase complex component E1

1

5

High-throughput

0.457

High

117029

J3KQN4
Ribosomal protein L36a

1

2

High-throughput

0.457

High

458693

SAP
Prosaposin

1

2

High-throughput

0.457

High

565917

EF2
Elongation factor 2

1

1

High-throughput

0.457

High

1156292

Q53Y06
ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E isoform 1

1

1

High-throughput

0.457

High

724087

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.439

High

959473

YPEL3
Protein yippee-like 3

1

2

High-throughput

0.439

High

1156291

KGUA
Guanylate kinase

1

0

High-throughput

0.438

High

64164

A5YM51
Myosin-7

1

10

High-throughput

0.417

High

94469

D6RFM5
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.417

High

1156293

Q5BJH1
PSAP protein

1

2

High-throughput

0.417

High

1156297

Q6FGX2
Troponin I, cardiac muscle

1

5

High-throughput

0.417

High

1156298

Q6LEU2
Sodium/potassium-transporting ATPase subunit beta

1

1

High-throughput

0.417

High

1156303

Q8IW09
Zinc finger protein 335

1

4

High-throughput

0.417

High

506727

PRR35
Proline-rich protein 35

2

0

High-throughput

0.316

High

1156296

BICRL
BRD4-interacting chromatin-remodeling complex-associated protein-like

2

0

High-throughput

0.316

High

1156319

SNX18
Sorting nexin-18

2

0

High-throughput

0.316

High

1156326

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.316

High

1156306

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.279

Low

1156316

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.279

Low

360272

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.265

Low

360722

COX3
Cytochrome c oxidase subunit 3

1

0

High-throughput

0.265

Low

388633

C1QA
Complement C1q subcomponent subunit A

1

0

High-throughput

0.265

Low

460826

CATB
Cathepsin B

1

0

High-throughput

0.265

Low

568426

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.265

Low

641301

PGS1
Biglycan

1

0

High-throughput

0.265

Low

941663

NDUA6
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6

1

0

High-throughput

0.265

Low

1156290

CP1B1
Cytochrome P450 1B1

1

0

High-throughput

0.265

Low

1156299

TATD1
Deoxyribonuclease TATDN1

1

0

High-throughput

0.265

Low

1156320

SDF2
Stromal cell-derived factor 2

1

0

High-throughput

0.265

Low

1156335

MYOZ2
Myozenin-2

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025