HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: SLAF1 (Q13291)
Signaling lymphocytic activation molecule (CDw150) (IPO-3) (SLAM family member 1) (CD antigen CD150)
Gene: SLAMF1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	11806999, 11689425, 11313386
Identification Methods	affinity chromatography technology, pull down, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0070374 - positive regulation of ERK1 and ERK2 cascade
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 335
+	Hs
		986050 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF5_HUMAN (15-334): 6.3e-54: 181: 21.21
+	Hs
		986027 PTN11_HUMAN (1-593): 0: 581: 100.00		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12
+	Hs
		986036 PTN11_HUMAN (1-593): 0: 581: 100.00		LY9_HUMAN (10-246): 1.54e-43: 160: 22.54
+	Hs
		986009 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF6_HUMAN (13-330): 2.04e-43: 154: 18.04
+	Hs
		532367 PTN11_HUMAN (1-593): 0: 581: 100.00		CEAM1_HUMAN (14-330): 2.03e-41: 153: 14.93
+	Hs
		986062 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL9_HUMAN (28-234): 3.1e-41: 151: 17.43
+	Hs
		986060 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL7_HUMAN (28-240): 1.96e-35: 135: 17.86
+	Hs
		665951 PTN6_HUMAN (6-593): 0: 531: 55.27		CD244_HUMAN (23-331): 5e-50: 172: 19.12
+	Hs
		665937 PTN6_HUMAN (6-593): 0: 531: 55.27		SLAF6_HUMAN (13-330): 2.04e-43: 154: 18.04
+	Hs
		532361 PTN6_HUMAN (6-593): 0: 531: 55.27		CEAM1_HUMAN (14-330): 2.03e-41: 153: 14.93
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (24-327): 1.1e-23: 103: 10.29
+	Mm
		682308 PTN11_MOUSE (1-593): 0: 580: 99.49		CEAM1_MOUSE (73-235): 3.84e-24: 104: 18.90
+	Hs
		665971 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL9_HUMAN (28-234): 3.1e-41: 151: 17.43
+	Hs
		665970 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL7_HUMAN (28-240): 1.96e-35: 135: 17.86
+	Hs
		589567 PTN11_HUMAN (1-593): 0: 581: 100.00		CD33_HUMAN (102-211): 9.8e-11: 64.1: 23.93
+	Hs
		601466 PTN6_HUMAN (6-593): 0: 531: 55.27		FGFR2_HUMAN (24-327): 1.1e-23: 103: 10.29
+	Hs
		589559 PTN6_HUMAN (6-593): 0: 531: 55.27		CD33_HUMAN (102-211): 9.8e-11: 64.1: 23.93
+	Hs
		507980 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		FGFR1_HUMAN (20-333): 4.68e-46: 168: 9.12
+	Hs
		68228 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		HECA2_HUMAN (1-329): 2.97e-24: 104: 17.39