HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: SLAF6 (Q96DU3)
SLAM family member 6 (Activating NK receptor) (NK-T-B-antigen) (NTB-A) (CD antigen CD352)
Gene: SLAMF6

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	11489943
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 332
+	Hs
		985949 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF1_HUMAN (1-313): 6.65e-63: 204: 18.68
+	Hs
		986027 PTN11_HUMAN (1-593): 0: 581: 100.00		CD244_HUMAN (22-331): 3.28e-59: 196: 16.36
+	Hs
		986050 PTN11_HUMAN (1-593): 0: 581: 100.00		SLAF5_HUMAN (2-332): 7.51e-56: 186: 25.36
+	Hs
		665937 PTN6_HUMAN (6-593): 0: 531: 55.27		SLAF6_HUMAN (1-332): 1.42e-70: 224: 100.00
+	Hs
		986036 PTN11_HUMAN (1-593): 0: 581: 100.00		LY9_HUMAN (4-277): 2.81e-44: 162: 28.01
+	Hs
		665951 PTN6_HUMAN (6-593): 0: 531: 55.27		CD244_HUMAN (22-331): 3.28e-59: 196: 16.36
+	Mm
		682308 PTN11_MOUSE (1-593): 0: 580: 99.49		CEAM1_MOUSE (23-312): 8.6e-30: 120: 13.03
+	Hs
		532367 PTN11_HUMAN (1-593): 0: 581: 100.00		CEAM1_HUMAN (9-315): 8.73e-28: 114: 12.42
+	Hs
		532361 PTN6_HUMAN (6-593): 0: 531: 55.27		CEAM1_HUMAN (9-315): 8.73e-28: 114: 12.42
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 531: 55.27		CD22_HUMAN (27-319): 1.21e-13: 73.7: 11.46
+	Mm
		665992 PTN6_MOUSE (6-583): 0: 530: 55.94		FCRL5_MOUSE (89-325): 6.55e-12: 68.4: 11.69
+	Mm
		665976 PTN6_MOUSE (6-583): 0: 530: 55.94		CD22_MOUSE (15-202): 8.18e-11: 65.3: 12.94
+	Hs
		68228 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		HECA2_HUMAN (2-330): 1.29e-51: 178: 14.41
+	Hs
		68222 PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85		HECA2_HUMAN (2-330): 1.29e-51: 178: 14.41
+	Hs
		1031992 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		CEA21_HUMAN (9-269): 1.95e-46: 160: 17.27
+	Hs
		489970 PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85		CEA21_HUMAN (9-269): 1.95e-46: 160: 17.27
+	Hs
		573657 PTN1_HUMAN (232-541): 4.38e-110: 338: 31.63		CXAR_HUMAN (2-325): 3.8e-51: 175: 12.17
+	Hs
		416911 PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29		CD2_HUMAN (6-326): 4.55e-55: 185: 16.57
+	Hs
		685236 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		CEAM8_HUMAN (14-243): 1.31e-18: 87.2: 12.39
+	Hs
		441175 PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29		CD22_HUMAN (27-319): 1.21e-13: 73.7: 11.46