HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: SIG11 (Q96RL6)
Sialic acid-binding Ig-like lectin 11 (Sialic acid-binding lectin 11) (Siglec-11)
Gene: SIGLEC11

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	11986327
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 698
+	Hs
		665942 PTN6_HUMAN (6-593): 0: 531: 55.27		SIG11_HUMAN (1-698): 2.88e-133: 410: 100.00
+	Hs
		986013 PTN11_HUMAN (1-593): 0: 581: 100.00		SIG10_HUMAN (28-672): 1.09e-103: 333: 68.43
+	Mm
		719313 PTN11_MOUSE (1-593): 0: 580: 99.49		SIG10_MOUSE (26-674): 3.65e-103: 332: 52.35
+	Hs
		177596 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Hs
		665940 PTN6_HUMAN (6-593): 0: 531: 55.27		SIG10_HUMAN (28-672): 1.09e-103: 333: 68.43
+	Hs
		177594 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL5_HUMAN (24-451): 2.26e-86: 283: 38.69
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (1-656): 1.2e-59: 219: 13.13
+	Hs
		665883 PTN6_HUMAN (6-593): 0: 531: 55.27		PTK7_HUMAN (1-656): 1.2e-59: 219: 13.13
+	Hs
		986062 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Hs
		986060 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL7_HUMAN (160-455): 2.09e-31: 130: 28.79
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 531: 55.27		CD22_HUMAN (75-662): 2.09e-42: 166: 17.41
+	Hs
		589567 PTN11_HUMAN (1-593): 0: 581: 100.00		CD33_HUMAN (372-674): 1.45e-25: 110: 22.76
+	Hs
		665971 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL9_HUMAN (160-454): 1.24e-41: 159: 29.65
+	Mm
		665976 PTN6_MOUSE (6-583): 0: 530: 55.94		CD22_MOUSE (99-466): 1.88e-31: 133: 21.93
+	Hs
		665970 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL7_HUMAN (160-455): 2.09e-31: 130: 28.79
+	Hs
		589559 PTN6_HUMAN (6-593): 0: 531: 55.27		CD33_HUMAN (372-674): 1.45e-25: 110: 22.76
+	Hs
		616927 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		NRCAM_HUMAN (26-698): 9.49e-51: 193: 11.47
+	Mm
		530202 PTPRA_MOUSE (33-522): 1.27e-110: 351: 23.52		NCAM1_MOUSE (33-674): 4.95e-38: 154: 12.86
+	Hs
		616914 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		CNTN1_HUMAN (419-654): 1.41e-10: 67: 9.27
+	Hs
		663992 PTN4_HUMAN (143-535): 1.5e-113: 362: 30.46		ICAM5_HUMAN (313-486): 4e-09: 62: 30.39