HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: KI2L4 (Q99706)
Killer cell immunoglobulin-like receptor 2DL4 (CD158 antigen-like family member D) (G9P) (Killer cell inhibitory receptor 103AS) (KIR-103AS) (MHC class I NK cell receptor KIR103AS) (CD antigen CD158d)
Gene: KIR2DL4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.50	0.489

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 377
+	Hs
		798184 PTN11_HUMAN (1-593): 0: 581: 100.00		KI2L3_HUMAN (3-338): 3.87e-107: 319: 63.05
+	Hs
		798139 PTN11_HUMAN (1-593): 0: 581: 100.00		KI2L1_HUMAN (3-341): 6.99e-105: 314: 62.79
+	Hs
		665820 PTN6_HUMAN (6-593): 0: 531: 55.27		KI2L3_HUMAN (3-338): 3.87e-107: 319: 63.05
+	Hs
		665819 PTN6_HUMAN (6-593): 0: 531: 55.27		KI2L1_HUMAN (3-341): 6.99e-105: 314: 62.79
+	Hs
		798232 PTN11_HUMAN (1-593): 0: 581: 100.00		KI3L1_HUMAN (3-356): 8.29e-70: 227: 40.06
+	Mm
		719307 PTN11_MOUSE (1-593): 0: 580: 99.49		LRB4A_MOUSE (3-318): 6.7e-59: 195: 23.91
+	Hs
		601501 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR2_HUMAN (39-370): 1.38e-53: 191: 12.96
+	Hs
		665921 PTN6_HUMAN (6-593): 0: 531: 55.27		LIRB4_HUMAN (3-375): 1.36e-74: 240: 27.52
+	Hs
		507959 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR1_HUMAN (34-370): 1.41e-52: 188: 13.39
+	Hs
		609260 PTN11_HUMAN (1-593): 0: 581: 100.00		FGFR3_HUMAN (34-370): 1.1e-52: 188: 12.84
+	Hs
		665821 PTN6_HUMAN (6-593): 0: 531: 55.27		KI3L1_HUMAN (3-356): 8.29e-70: 227: 40.06
+	Hs
		252776 PTN6_HUMAN (6-593): 0: 531: 55.27		LIRB3_HUMAN (13-358): 1.84e-64: 218: 29.46
+	Hs
		665922 PTN6_HUMAN (6-593): 0: 531: 55.27		LIRB1_HUMAN (13-376): 2.22e-62: 213: 27.27
+	Hs
		665916 PTN6_HUMAN (6-593): 0: 531: 55.27		LIRB2_HUMAN (26-358): 1.1e-58: 201: 27.73
+	Hs
		601466 PTN6_HUMAN (6-593): 0: 531: 55.27		FGFR2_HUMAN (39-370): 1.38e-53: 191: 12.96
+	Hs
		985972 PTN11_HUMAN (1-593): 0: 581: 100.00		LAIR1_HUMAN (3-138): 4.74e-37: 137: 27.27
+	Mm
		719316 PTN11_MOUSE (1-593): 0: 580: 99.49		Q8K4V6_MOUSE (31-243): 1.52e-33: 133: 25.78
+	Mm
		719293 PTN11_MOUSE (1-593): 0: 580: 99.49		LIRB3_MOUSE (23-317): 2.05e-28: 118: 20.52
+	Hs
		665902 PTN6_HUMAN (6-593): 0: 531: 55.27		LAIR1_HUMAN (3-138): 4.74e-37: 137: 27.27
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 531: 55.27		CD22_HUMAN (23-243): 7.4e-12: 68.7: 15.93