HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: DAPP1 (Q9UN19)
Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (hDAPP1) (B lymphocyte adapter protein Bam32) (B-cell adapter molecule of 32 kDa)
Gene: DAPP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~Y_phosphatase
Common GO terms	GO:0005829 - cytosol GO:0006470 - protein dephosphorylation
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 280
+	Hs
		412146 PTN11_HUMAN (1-593): 0: 581: 100.00		FYN_HUMAN (4-280): 4.46e-57: 193: 18.77
+	Hs
		522931 PTN11_HUMAN (1-593): 0: 581: 100.00		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Mm
		337619 PTN11_MOUSE (1-593): 0: 580: 99.49		ABL1_MOUSE (8-280): 3.6e-50: 179: 17.61
+	Hs
		522804 PTN6_HUMAN (6-593): 0: 531: 55.27		SRC_HUMAN (4-280): 1.79e-56: 191: 18.09
+	Hs
		433603 PTN6_HUMAN (6-593): 0: 531: 55.27		LYN_HUMAN (3-280): 2.64e-55: 187: 18.37
+	Mm
		639436 PTN6_MOUSE (6-583): 0: 530: 55.94		LYN_MOUSE (3-280): 2.45e-55: 187: 18.37
+	Hs
		337361 PTN6_HUMAN (6-593): 0: 531: 55.27		ABL1_HUMAN (8-280): 6.5e-51: 181: 17.61
+	Hs
		411612 PTN6_HUMAN (6-593): 0: 531: 55.27		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Mm
		719286 PTN11_MOUSE (1-593): 0: 580: 99.49		PTN11_MOUSE (35-225): 1.49e-29: 119: 22.28
+	Hs
		985941 PTN11_HUMAN (1-593): 0: 581: 100.00		PTN11_HUMAN (35-225): 1.69e-29: 118: 22.28
+	Hs
		580985 PTN11_HUMAN (1-593): 0: 581: 100.00		PLCG1_HUMAN (4-184): 1.67e-22: 99.1: 23.00
+	Hs
		665872 PTN11_HUMAN (1-593): 0: 581: 100.00		PTN6_HUMAN (35-184): 4.37e-22: 97.5: 25.31
+	Hs
		562641 PTN11_HUMAN (1-593): 0: 581: 100.00		PLCG2_HUMAN (8-198): 3.87e-21: 94.8: 20.28
+	Hs
		580938 PTN6_HUMAN (6-593): 0: 531: 55.27		PLCG1_HUMAN (4-184): 1.67e-22: 99.1: 23.00
+	Hs
		665798 PTN6_HUMAN (6-593): 0: 531: 55.27		PTN6_HUMAN (35-184): 4.37e-22: 97.5: 25.31
+	Hs
		562628 PTN6_HUMAN (6-593): 0: 531: 55.27		PLCG2_HUMAN (8-198): 3.87e-21: 94.8: 20.28
+	Hs
		412016 PTPRD_HUMAN (39-522): 2.1e-115: 379: 26.76		FYN_HUMAN (4-280): 4.46e-57: 193: 18.77
+	Hs
		411596 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		LCK_HUMAN (3-280): 6.43e-53: 181: 20.07
+	Hs
		616905 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		CSK_HUMAN (10-280): 6.53e-43: 153: 13.07