HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: GAB2 (Q9UQC2)
GRB2-associated-binding protein 2 (GRB2-associated binder 2) (Growth factor receptor bound protein 2-associated protein 2) (pp100)
Gene: GAB2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	16371368, 12135708, 11782427, 10391903, 11334882, 10871282, 19909739, 14982882, 15356145, 26839216, 9660791, 11027663, 21636860, 15170389, 19172738, 16253990
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 593 Hs			1 676
+	Hs
		665968 PTN6_HUMAN (6-593): 0: 531: 55.27		GAB2_HUMAN (1-676): 0: 763: 100.00
+	Mm
		719303 PTN11_MOUSE (1-593): 0: 580: 99.49		Q3ZB59_MOUSE (1-676): 0: 714: 91.31
+	Mm
		719323 PTN11_MOUSE (1-593): 0: 580: 99.49		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Mm
		665998 PTN6_MOUSE (6-583): 0: 530: 55.94		GAB2_MOUSE (1-676): 0: 714: 91.16
+	Hs
		985952 PTN11_HUMAN (1-593): 0: 581: 100.00		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Mm
		719319 PTN11_MOUSE (1-593): 0: 580: 99.49		GAB1_MOUSE (3-675): 0: 643: 37.45
+	Hs
		986000 PTN11_HUMAN (1-593): 0: 581: 100.00		GAB3_HUMAN (3-667): 7.57e-162: 479: 31.42
+	Hs
		616917 PTPRB_HUMAN (147-555): 2.35e-115: 379: 27.91		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		1020092 PTPRJ_HUMAN (146-528): 1.52e-109: 359: 30.55		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		577020 PTPRA_HUMAN (33-522): 7.08e-110: 349: 23.72		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		441197 PTPRC_HUMAN (33-579): 2.25e-85: 291: 18.29		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		617108 PTPRG_HUMAN (33-527): 9.52e-62: 223: 17.05		GAB1_HUMAN (3-675): 0: 652: 37.36
+	Hs
		665957 PTN6_HUMAN (6-593): 0: 531: 55.27		PKHA2_HUMAN (2-229): 1.67e-55: 197: 21.55
+	Hs
		986058 PTN11_HUMAN (1-593): 0: 581: 100.00		DAPP1_HUMAN (9-125): 1.95e-26: 111: 27.27
+	Dm
		665797 CSW_DROME (1-317): 7.21e-59: 212: 64.35		DOS_DROME (8-218): 1.26e-36: 149: 30.22