HitPredict

Interactor 1: PTN11 (Q06124)
Tyrosine-protein phosphatase non-receptor type 11 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1D) (PTP-1D) (Protein-tyrosine phosphatase 2C) (PTP-2C) (SH-PTP2) (SHP-2) (Shp2) (SH-PTP3)
Gene: PTPN11

Interactor 2: SIGL7 (Q9Y286)
Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
Gene: SIGLEC7

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.50	0.533

Property	Details
Experiments	15703304, 17138568
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 593 Hs			1 467
+	Hs
		986062 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL9_HUMAN (11-467): 5.54e-92: 288: 73.71
+	Hs
		665970 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL7_HUMAN (11-467): 9.73e-101: 311: 100.00
+	Hs
		665971 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL9_HUMAN (11-467): 5.54e-92: 288: 73.71
+	Hs
		177596 PTN11_HUMAN (1-593): 0: 581: 100.00		SIGL5_HUMAN (39-467): 8.62e-35: 138: 18.74
+	Hs
		986018 PTN11_HUMAN (1-593): 0: 581: 100.00		SIG11_HUMAN (77-466): 5.96e-32: 131: 23.46
+	Hs
		985950 PTN11_HUMAN (1-593): 0: 581: 100.00		PTK7_HUMAN (22-446): 2.06e-31: 130: 11.94
+	Mm
		719313 PTN11_MOUSE (1-593): 0: 580: 99.49		SIG10_MOUSE (29-466): 4.67e-26: 113: 15.43
+	Hs
		986013 PTN11_HUMAN (1-593): 0: 581: 100.00		SIG10_HUMAN (77-465): 1.82e-25: 111: 15.13
+	Hs
		589567 PTN11_HUMAN (1-593): 0: 581: 100.00		CD33_HUMAN (145-465): 8.84e-26: 109: 18.38
+	Hs
		581691 PTN11_HUMAN (1-593): 0: 581: 100.00		VCAM1_HUMAN (107-363): 1.98e-19: 93.3: 18.02
+	Hs
		177594 PTN6_HUMAN (6-593): 0: 531: 55.27		SIGL5_HUMAN (39-467): 8.62e-35: 138: 18.74
+	Hs
		665942 PTN6_HUMAN (6-593): 0: 531: 55.27		SIG11_HUMAN (77-466): 5.96e-32: 131: 23.46
+	Hs
		665883 PTN6_HUMAN (6-593): 0: 531: 55.27		PTK7_HUMAN (22-446): 2.06e-31: 130: 11.94
+	Hs
		665940 PTN6_HUMAN (6-593): 0: 531: 55.27		SIG10_HUMAN (77-465): 1.82e-25: 111: 15.13
+	Hs
		589559 PTN6_HUMAN (6-593): 0: 531: 55.27		CD33_HUMAN (145-465): 8.84e-26: 109: 18.38
+	Hs
		590601 PTN6_HUMAN (6-593): 0: 531: 55.27		CD22_HUMAN (31-354): 2.73e-23: 105: 16.31
+	Mm
		665976 PTN6_MOUSE (6-583): 0: 530: 55.94		CD22_MOUSE (20-365): 6.37e-22: 101: 17.61
+	Hs
		68228 PTPRS_HUMAN (39-522): 8.52e-117: 384: 26.76		HECA2_HUMAN (28-374): 1.87e-19: 92.6: 17.88
+	Dm
		1308480 Q9W4F5_DROME (191-560): 1.41e-112: 371: 29.38		Q9BN17_DROME (32-327): 3.2e-21: 99.1: 20.83
+	Hs
		68222 PTPRF_HUMAN (33-522): 2.6e-112: 371: 25.85		HECA2_HUMAN (28-374): 1.87e-19: 92.6: 17.88