HitPredict

Interactor 1: SGD1 (Q06132)
Suppressor of glycerol defect protein 1
Gene: SGD1

Interactor 2: FAL1 (Q12099)
ATP-dependent RNA helicase FAL1 (EC 3.6.4.13) (Translation initiation factor four A-like protein 1)
Gene: FAL1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.877

Property	Details
Experiments	29054886, 31994962, 21576267
Identification Methods	two hybrid, affinity chromatography technology, pull down, cross-linking study, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	DEAD~MA3, Helicase_C~MA3, DEAD~MIF4G, Helicase_C~MIF4G
Common GO terms	GO:0000462 - maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0005730 - nucleolus GO:0030490 - maturation of SSU-rRNA GO:0032040 - small-subunit processome GO:0097078 - FAL1-SGD1 complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 899 Sc			1 399
+	Hs
		757643 NOM1_HUMAN (9-890): 2.28e-153: 474: 20.99		IF4A3_HUMAN (3-398): 7.9e-133: 388: 60.86
+	Dm
		1367481 CWC22_DROME (2-861): 7.63e-128: 418: 14.85		IF4A3_DROME (2-398): 7.53e-134: 390: 61.71
+	Hs
		979902 IF4G1_HUMAN (68-636): 3.6e-91: 318: 11.31		IF4A2_HUMAN (16-398): 5.42e-168: 477: 59.01
+	Hs
		892779 IF4G1_HUMAN (68-636): 3.6e-91: 318: 11.31		IF4A1_HUMAN (16-398): 1.2e-167: 476: 59.79
+	Mm
		892952 IF4G1_MOUSE (68-636): 9.49e-89: 311: 11.11		IF4A1_MOUSE (16-398): 1.2e-167: 476: 59.79
+	Hs
		757770 CWC22_HUMAN (201-867): 5.45e-122: 393: 14.06		IF4A3_HUMAN (3-398): 7.9e-133: 388: 60.86
+	Dm
		972132 Q5KTT4_DROME (6-644): 5.54e-99: 341: 13.78		IF4A_DROME (20-398): 4.11e-150: 432: 60.42
+	Hs
		203371 IF4G3_HUMAN (44-583): 4.73e-80: 286: 11.05		IF4A2_HUMAN (16-398): 5.42e-168: 477: 59.01
+	Hs
		203355 IF4G3_HUMAN (44-583): 4.73e-80: 286: 11.05		IF4A1_HUMAN (16-398): 1.2e-167: 476: 59.79
+	Dm
		247403 O61380_DROME (48-614): 7.93e-83: 294: 11.72		IF4A_DROME (20-398): 4.11e-150: 432: 60.42
+	Hs
		757578 IF4G1_HUMAN (68-636): 3.6e-91: 318: 11.31		IF4A3_HUMAN (3-398): 7.9e-133: 388: 60.86
+	Hs
		133990 IF4G1_HUMAN (68-636): 3.6e-91: 318: 11.31		DDX3X_HUMAN (1-399): 3.92e-129: 387: 28.50
+	Sc
		485737 IF4F2_YEAST (4-624): 8.25e-78: 273: 13.42		IF4A_YEAST (20-398): 1.91e-135: 394: 56.73
+	Sc
		485736 IF4F1_YEAST (5-615): 3.5e-73: 261: 10.98		IF4A_YEAST (20-398): 1.91e-135: 394: 56.73
+	Sc
		415981 IF4F2_YEAST (4-624): 8.25e-78: 273: 13.42		DED1_YEAST (1-397): 5.7e-127: 380: 31.25
+	Sc
		624098 IF4F1_YEAST (5-615): 3.5e-73: 261: 10.98		DBP2_YEAST (6-397): 1.11e-128: 382: 29.75
+	Sc
		415980 IF4F1_YEAST (5-615): 3.5e-73: 261: 10.98		DED1_YEAST (1-397): 5.7e-127: 380: 31.25
+	Hs
		640441 IF4G1_HUMAN (68-636): 3.6e-91: 318: 11.31		DDX6_HUMAN (9-394): 5.3e-95: 294: 41.18
+	Hs
		203341 IF4G3_HUMAN (44-583): 4.73e-80: 286: 11.05		DDX6_HUMAN (9-394): 5.3e-95: 294: 41.18
+	Dm
		247399 O61380_DROME (48-614): 7.93e-83: 294: 11.72		DDX6_DROME (12-392): 6.38e-92: 285: 40.31