HitPredict

Interactor 1: BTK (Q06187)
Tyrosine-protein kinase BTK (EC 2.7.10.2) (Agammaglobulinemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Bruton tyrosine kinase)
Gene: BTK

Interactor 2: IBTK (Q9P2D0)
Inhibitor of Bruton tyrosine kinase (IBtk)
Gene: IBTK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.75	1.00	0.870

Property	Details
Experiments	11577348, 21482705, 18596081
Identification Methods	affinity chromatography technology, pull down, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ank_2~SH3_1
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 659 Hs			1 1353
+	Hs
		996574 ITK_HUMAN (4-657): 0: 688: 49.09		IBTK_HUMAN (1-1353): 0: 1106: 100.00
+	Hs
		781346 BTK_HUMAN (1-659): 0: 790: 100.00		BCL6_HUMAN (736-1188): 2.12e-74: 264: 17.99
+	Hs
		781320 ABL2_HUMAN (169-659): 5.79e-163: 500: 37.70		BCL6_HUMAN (736-1188): 2.12e-74: 264: 17.99
+	Hs
		337485 ABL1_HUMAN (181-659): 2.77e-165: 505: 38.76		HERC1_HUMAN (130-455): 4.25e-63: 240: 20.59
+	Hs
		307239 YES_HUMAN (133-653): 5.05e-180: 523: 32.77		RCBT2_HUMAN (23-313): 7.66e-47: 179: 21.38
+	Hs
		412245 FYN_HUMAN (155-653): 0: 529: 34.35		NEK8_HUMAN (249-427): 7.01e-12: 72.1: 20.42
+	Hs
		337497 ABL1_HUMAN (181-659): 2.77e-165: 505: 38.76		NEK8_HUMAN (249-427): 7.01e-12: 72.1: 20.42
+	Ce
		371301 ABL1_CAEEL (220-659): 9.94e-89: 302: 37.42		SPOP_CAEEL (778-930): 2.46e-12: 72.8: 29.41