HitPredict

Interactor 1: TYRO3 (Q06418)
Tyrosine-protein kinase receptor TYRO3 (EC 2.7.10.1) (Tyrosine-protein kinase BYK) (Tyrosine-protein kinase DTK) (Tyrosine-protein kinase RSE) (Tyrosine-protein kinase SKY) (Tyrosine-protein kinase TIF)
Gene: TYRO3

Interactor 2: HYOU1 (Q9Y4L1)
Hypoxia up-regulated protein 1 (150 kDa oxygen-regulated protein) (ORP-150) (170 kDa glucose-regulated protein) (GRP-170) (Heat shock protein family H member 4)
Gene: HYOU1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.500

Property	Details
Experiments	35384245
Identification Methods	affinity chromatography technology
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005524 - ATP binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 890 Hs			1 999
+	Hs
		665690 EPHB2_HUMAN (72-826): 1.04e-178: 546: 20.21		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		665546 EPHA8_HUMAN (116-808): 3.82e-166: 511: 20.03		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		972379 TIE2_HUMAN (37-796): 3.68e-160: 499: 23.35		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		1072565 EPHA7_HUMAN (116-823): 2.21e-172: 528: 20.33		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		665505 EPHA8_HUMAN (116-808): 3.82e-166: 511: 20.03		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		320817 EPHA8_HUMAN (116-808): 3.82e-166: 511: 20.03		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		1128944 EPHAA_HUMAN (203-842): 1.14e-129: 416: 23.35		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		320868 EPHAA_HUMAN (203-842): 1.14e-129: 416: 23.35		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		441591 MET_HUMAN (495-790): 3.89e-65: 240: 41.67		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		435811 IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Hs
		411535 INSR_HUMAN (292-790): 2.17e-60: 226: 31.15		HYOU1_HUMAN (1-999): 0: 859: 100.00
+	Mm
		555006 MET_MOUSE (495-790): 6.45e-65: 239: 41.67		HS105_MOUSE (33-970): 0: 818: 24.84
+	Hs
		411458 INSR_HUMAN (292-790): 2.17e-60: 226: 31.15		HS105_HUMAN (33-960): 0: 812: 24.46
+	Hs
		441447 MET_HUMAN (495-790): 3.89e-65: 240: 41.67		HSP74_HUMAN (33-964): 0: 785: 25.64
+	Hs
		320797 IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		320795 INSR_HUMAN (292-790): 2.17e-60: 226: 31.15		HS74L_HUMAN (33-960): 0: 793: 24.57
+	Hs
		503499 EPHB2_HUMAN (72-826): 1.04e-178: 546: 20.21		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Rn
		544811 INSR_RAT (232-788): 7.04e-127: 416: 27.65		HSP7C_RAT (682-815): 1.96e-30: 130: 16.42
+	Hs
		435511 IGF1R_HUMAN (333-779): 3.39e-61: 228: 32.53		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42
+	Hs
		503944 RON_HUMAN (500-793): 2.58e-59: 223: 41.95		HSP7C_HUMAN (682-815): 2.07e-30: 130: 16.42