Interactor 1: CAN2 (Q07009)
Calpain-2 catalytic subunit (EC 3.4.22.53) (Calcium-activated neutral proteinase 2) (CANP 2) (Calpain M-type) (Calpain-2 large subunit) (Millimolar-calpain) (M-calpain)
Gene: Capn2

Interactor 2: CPNS1 (Q64537)
Calpain small subunit 1 (CSS1) (Calcium-activated neutral proteinase small subunit) (CANP small subunit) (Calcium-dependent protease small subunit) (CDPS) (Calcium-dependent protease small subunit 1) (Calpain regulatory subunit)
Gene: Capns1

Species: Rattus norvegicus

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.84 1.00 0.919

The method score is based on:

Property Details
Experiments 10417423, 19020623, 19020622, 15476820, 10601010
Identification Methods x-ray crystallography, molecular sieving
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Calpain_III~EF-hand_8, EF-hand_8~EF-hand_8
Common GO terms GO:0004198 - calcium-dependent cysteine-type endopeptidase activity
GO:0005509 - calcium ion binding
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0030163 - protein catabolic process
and 2 others

more...

Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 700
Rn

1 270
+ Hs
+ Hs
+ Hs
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+ Hs
+ Hs
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+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Dm
+ Hs
+ Hs

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Last updated: 15 Jul 2024