Protein: GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3 (G(i) alpha-3)

Gene: GNAI3
Organism: Homo sapiens
Interactions: 227
UniProt ID: P08754

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

220434

RGS14
Regulator of G-protein signaling 14

8

20

Small-scale

0.968

High

475990

GPSM1
G-protein-signaling modulator 1

6

15

Small-scale

0.952

High

476064

GPSM3
G-protein-signaling modulator 3

5

3

High-throughput

0.926

High

168030

RGS12
Regulator of G-protein signaling 12

5

20

Small-scale

0.924

High

476042

RIC8A
Chaperone Ric-8A

5

14

Small-scale

0.924

High

475922

RGS19
Regulator of G-protein signaling 19

4

20

Small-scale

0.896

High

475941

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

4

11

High-throughput

0.895

High

418571

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

4

12

High-throughput

0.892

High

475915

RPGP1
Rap1 GTPase-activating protein 1

4

4

High-throughput

0.892

High

475948

GPSM2
G-protein-signaling modulator 2

4

14

Small-scale

0.884

High

475916

MTR1A
Melatonin receptor type 1A

3

20

Small-scale

0.866

High

475876

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

3

12

High-throughput

0.861

High

475887

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

3

11

High-throughput

0.861

High

475989

AN13B
Ankyrin repeat domain-containing protein 13B

3

3

High-throughput

0.861

High

475991

PCP2
Purkinje cell protein 2 homolog

4

11

High-throughput

0.796

High

475919

MTR1B
Melatonin receptor type 1B

2

19

Small-scale

0.789

High

476047

RGS18
Regulator of G-protein signaling 18

2

20

Small-scale

0.778

High

192031

RGS16
Regulator of G-protein signaling 16

2

20

Small-scale

0.768

High

193879

RGS5
Regulator of G-protein signaling 5

2

20

Small-scale

0.768

High

475939

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

8

20

Small-scale

0.750

High

475890

S1PR1
Sphingosine 1-phosphate receptor 1

1

20

Small-scale

0.740

High

476055

RGS17
Regulator of G-protein signaling 17

1

20

High-throughput

0.740

High

223463

RGS10
Regulator of G-protein signaling 10

1

20

Small-scale

0.724

High

475940

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

5

20

Small-scale

0.714

High

476036

GBB4
Guanine nucleotide-binding protein subunit beta-4

5

20

Small-scale

0.714

High

475976

GRDN
Girdin

4

7

Small-scale

0.700

High

243463

GBG7

4

20

High-throughput

0.691

High

475927

GBG10

4

20

High-throughput

0.691

High

475944

GBG5

4

20

High-throughput

0.691

High

475926

GBG4

3

20

High-throughput

0.667

High

475935

GBG11

3

20

High-throughput

0.667

High

476011

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

3

4

High-throughput

0.667

High

476050

DAPLE
Protein Daple

3

8

Small-scale

0.664

High

475908

RGS2
Regulator of G-protein signaling 2

1

20

Small-scale

0.647

High

476023

ACE2
Angiotensin-converting enzyme 2

3

3

Small-scale

0.640

High

475930

CLH2
Clathrin heavy chain 2

3

0

High-throughput

0.638

High

476020

DCNL5
DCN1-like protein 5

3

0

High-throughput

0.638

High

476021

NDC1
Nucleoporin NDC1

3

0

High-throughput

0.638

High

476030

TM222
Transmembrane protein 222

3

0

High-throughput

0.638

High

362633

EGFR
Epidermal growth factor receptor

2

9

Small-scale

0.624

High

270425

FZD7
Frizzled-7

1

2

Small-scale

0.618

High

458244

ADRB2
Beta-2 adrenergic receptor

1

11

High-throughput

0.618

High

475891

CNR1
Cannabinoid receptor 1

1

20

Small-scale

0.618

High

475911

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

475923

RGS3
Regulator of G-protein signaling 3

1

20

Small-scale

0.618

High

475924

RGS7
Regulator of G-protein signaling 7

1

20

Small-scale

0.618

High

475982

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.618

High

476007

ASB11
Ankyrin repeat and SOCS box protein 11

1

4

High-throughput

0.618

High

476035

ECT2
Protein ECT2

1

14

High-throughput

0.618

High

475934

CD81
CD81 antigen

2

8

Small-scale

0.601

High

375106

RASK
GTPase KRas

2

13

High-throughput

0.584

High

411220

NTRK1
High affinity nerve growth factor receptor

2

8

High-throughput

0.584

High

475907

CCNF
Cyclin-F

2

4

High-throughput

0.584

High

476043

ANLN
Anillin

2

9

High-throughput

0.584

High

476061

PHF24
PHD finger protein 24

2

0

High-throughput

0.580

High

475892

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

16

Small-scale

0.575

High

475925

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

12

High-throughput

0.575

High

475954

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

12

High-throughput

0.575

High

475994

AN13A
Ankyrin repeat domain-containing protein 13A

1

3

High-throughput

0.575

High

475898

CALX
Calnexin

2

1

High-throughput

0.571

High

475980

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

476053

GBG12

2

20

High-throughput

0.571

High

475902

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

2

Small-scale

0.561

High

475968

RASA3
Ras GTPase-activating protein 3

1

16

Small-scale

0.561

High

325202

SOX30
Transcription factor SOX-30

1

3

High-throughput

0.541

High

475931

AT12A
Potassium-transporting ATPase alpha chain 2

1

6

High-throughput

0.541

High

475895

AVR2A
Activin receptor type-2A

1

3

High-throughput

0.536

High

475900

UFO
Tyrosine-protein kinase receptor UFO

1

10

High-throughput

0.536

High

475958

STK3
Serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

475963

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

5

High-throughput

0.536

High

475988

PIM3
Serine/threonine-protein kinase pim-3

1

7

High-throughput

0.536

High

475996

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

476003

TBCK
TBC domain-containing protein kinase-like protein

1

4

High-throughput

0.536

High

476005

HASP
Serine/threonine-protein kinase haspin

1

4

High-throughput

0.536

High

476040

KC1G1
Casein kinase I isoform gamma-1

1

1

High-throughput

0.536

High

476051

PAK5
Serine/threonine-protein kinase PAK 5

1

12

High-throughput

0.536

High

476059

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.536

High

475896

DPP4
Dipeptidyl peptidase 4

1

2

High-throughput

0.515

High

475904

BASI
Basigin

1

3

High-throughput

0.515

High

388931

FINC
Fibronectin

1

0

High-throughput

0.513

High

475960

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

475984

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.513

High

476049

GTSE1
G2 and S phase-expressed protein 1

1

0

High-throughput

0.513

High

159309

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

8

Small-scale

0.501

High

475885

PGFRA
Platelet-derived growth factor receptor alpha

1

5

High-throughput

0.500

High

475932

EPHA4
Ephrin type-A receptor 4

1

7

High-throughput

0.500

High

475972

NTRK2
BDNF/NT-3 growth factors receptor

1

8

High-throughput

0.500

High

166611

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

3

High-throughput

0.489

High

475905

SYUA
Alpha-synuclein

1

2

High-throughput

0.481

High

475913

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.481

High

475947

NUCB2
Nucleobindin-2

1

7

High-throughput

0.481

High

475953

NUCB1
Nucleobindin-1

1

7

High-throughput

0.481

High

125164

LEG9
Galectin-9

1

2

High-throughput

0.479

High

475897

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

475899

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

164228

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

178151

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

188790

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

190793

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

1

High-throughput

0.479

High

217742

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

225919

STX6
Syntaxin-6

1

2

High-throughput

0.479

High

247617

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

293091

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

330593

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

347480

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

370977

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

459196

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

466076

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

475877

FURIN
Furin

1

2

High-throughput

0.479

High

475878

ANDR
Androgen receptor

1

10

High-throughput

0.479

High

475880

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

475881

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

475882

IFM1
Interferon-induced transmembrane protein 1

1

5

High-throughput

0.479

High

475884

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

475886

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

1

20

Small-scale

0.479

High

475889

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.479

High

475893

OSBP1
Oxysterol-binding protein 1

1

2

High-throughput

0.479

High

475903

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

475910

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.479

High

475914

YAP1
Transcriptional coactivator YAP1

1

12

High-throughput

0.479

High

475918

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

475920

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

1

High-throughput

0.479

High

475928

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

475929

PLK1
Serine/threonine-protein kinase PLK1

1

5

High-throughput

0.479

High

475936

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.479

High

475937

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.479

High

475942

DYLT1
Dynein light chain Tctex-type 1

1

1

High-throughput

0.479

High

475943

GBG3

1

20

High-throughput

0.479

High

475945

ACTC
Actin, alpha cardiac muscle 1

1

2

High-throughput

0.479

High

475946

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

475949

VIGLN
Vigilin

1

1

High-throughput

0.479

High

475950

IFM3
Interferon-induced transmembrane protein 3

1

5

High-throughput

0.479

High

475952

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

475956

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

10

High-throughput

0.479

High

475957

TFCP2
Alpha-globin transcription factor CP2

1

9

High-throughput

0.479

High

475961

GAB1
GRB2-associated-binding protein 1

1

9

Small-scale

0.479

High

475964

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.479

High

475965

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

475969

TNIP1
TNFAIP3-interacting protein 1

1

12

High-throughput

0.479

High

475970

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

475973

FSCN1
Fascin

1

1

High-throughput

0.479

High

475975

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.479

High

475978

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

475979

MIDN
Midnolin

1

3

High-throughput

0.479

High

475985

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

475997

NIN
Ninein

1

3

High-throughput

0.479

High

475998

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

476000

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

476001

PLD5
Inactive phospholipase D5

1

1

High-throughput

0.479

High

476004

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

10

High-throughput

0.479

High

476008

CLC4D
C-type lectin domain family 4 member D

1

4

High-throughput

0.479

High

476010

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

476013

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

476014

OPTN
Optineurin

1

11

High-throughput

0.479

High

476015

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

476018

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

9

High-throughput

0.479

High

476019

DUS9
Dual specificity protein phosphatase 9

1

16

High-throughput

0.479

High

476025

TRI31
E3 ubiquitin-protein ligase TRIM31

1

7

High-throughput

0.479

High

476028

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

1

High-throughput

0.479

High

476029

SIK2
Serine/threonine-protein kinase SIK2

1

1

Small-scale

0.479

High

476031

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

476032

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

2

Small-scale

0.479

High

476033

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

476034

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

476037

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

476038

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

9

High-throughput

0.479

High

476044

AAAS
Aladin

1

2

High-throughput

0.479

High

476045

TMPS4
Transmembrane protease serine 4

1

4

High-throughput

0.479

High

476046

DUS22
Dual specificity protein phosphatase 22

1

15

High-throughput

0.479

High

476048

RNF12
E3 ubiquitin-protein ligase RLIM

1

6

High-throughput

0.479

High

476052

SYLC
Leucine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

476054

HDAC6
Protein deacetylase HDAC6

1

7

High-throughput

0.479

High

476056

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

476060

CLC4E
C-type lectin domain family 4 member E

1

4

High-throughput

0.479

High

476062

RNF6
E3 ubiquitin-protein ligase RNF6

1

6

High-throughput

0.479

High

476065

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

320611

UBXN7
UBX domain-containing protein 7

1

0

High-throughput

0.458

High

475894

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

475901

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

475921

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

475938

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

475955

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

475959

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

475967

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

475981

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

475995

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

476022

DERL1
Derlin-1

1

0

High-throughput

0.458

High

476026

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

476057

SEPT9
Septin-9

1

0

Small-scale

0.458

High

476066

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

0

High-throughput

0.458

High

476067

ALG6
Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.458

High

254752

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

337065

NPT2B
Sodium-dependent phosphate transport protein 2B

1

3

High-throughput

0.445

High

475879

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

475883

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.445

High

475909

S19A1
Reduced folate transporter

1

5

High-throughput

0.445

High

475912

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.445

High

475917

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.445

High

475933

TERA
Transitional endoplasmic reticulum ATPase

1

6

High-throughput

0.445

High

475951

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

475962

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.445

High

475966

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

12

High-throughput

0.445

High

475977

S22A6
Solute carrier family 22 member 6

1

6

High-throughput

0.445

High

475983

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

475986

TBA1A
Tubulin alpha-1A chain

1

2

High-throughput

0.445

High

475999

CD177
CD177 antigen

1

5

Small-scale

0.445

High

476006

CTL1
Choline transporter-like protein 1

1

6

High-throughput

0.445

High

476016

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

476017

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

476024

S19A3
Thiamine transporter 2

1

5

High-throughput

0.445

High

476027

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

476039

ANKH
Mineralization regulator ANKH

1

2

High-throughput

0.445

High

476041

SO1B3
Solute carrier organic anion transporter family member 1B3

1

4

High-throughput

0.445

High

476058

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.445

High

476063

DAAM1
Disheveled-associated activator of morphogenesis 1

1

1

High-throughput

0.445

High

352299

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

475974

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

476009

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.437

High

476012

PLD4
5'-3' exonuclease PLD4

1

1

High-throughput

0.437

High

475888

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

475906

S26A3
Chloride anion exchanger

1

0

High-throughput

0.426

High

475971

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

0

High-throughput

0.426

High

475993

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.426

High

47862

A0AUL9
ATG2A protein

1

1

High-throughput

0.407

High

475992

S22A9
Organic anion transporter 7

1

6

High-throughput

0.407

High

475987

PKHH3
Pleckstrin homology domain-containing family H member 3

1

0

High-throughput

0.279

Low

476002

RDH13
Retinol dehydrogenase 13

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025