HitPredict

Interactor 1: PDE4B (Q07343)
3',5'-cyclic-AMP phosphodiesterase 4B (EC 3.1.4.53) (DPDE4) (PDE32) (cAMP-specific phosphodiesterase 4B)
Gene: PDE4B

Interactor 2: PDE4D (Q08499)
3',5'-cyclic-AMP phosphodiesterase 4D (EC 3.1.4.53) (DPDE3) (PDE43) (cAMP-specific phosphodiesterase 4D)
Gene: PDE4D

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.64 1.00 0.802

The method score is based on:

Property Details
Experiments 28514442, 33961781
Identification Methods affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains PDE4_UCR~PDE4_UCR, PDE4_UCR~PDEase_I, PDEase_I~PDEase_I
Common GO terms GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005246 - calcium channel regulator activity
GO:0005634 - nucleus
GO:0005813 - centrosome
GO:0005829 - cytosol
and 15 others

more...
Homologous interactions 8

Homologous interactions

Color coding for hit scores

1 736
Hs

1 809
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Last updated: 15 Jul 2024