HitPredict

Interactor 1: B2CL1 (Q07817)
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
Gene: BCL2L1

Interactor 2: BIK (Q13323)
Bcl-2-interacting killer (Apoptosis inducer NBK) (BIP1) (BP4)
Gene: BIK

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	0.60	0.760

Property	Details
Experiments	15694340, 27107012, 12853473, 32296183, 15721256, 16697956, 16189514, 26871637, 11342619, 9027312, unassigned1304, 31515488
Identification Methods	affinity chromatography technology, two hybrid, unspecified method, anti tag coimmunoprecipitation, fluorescence polarization spectroscopy, barcode fusion genetics two hybrid, two hybrid array, two hybrid prey pooling approach, surface plasmon resonance, validated two hybrid and 1 others more... two hybrid pooling approach
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008584 - male gonad development GO:0008637 - apoptotic mitochondrial changes GO:0097136 - Bcl-2 family protein complex
Homologous interactions	6

Homologous interactions

Color coding for hit scores

	1 233 Hs			1 160
+	Hs
		489410 BCL2_HUMAN (5-231): 3.01e-71: 219: 44.16		BIK_HUMAN (1-160): 3.76e-101: 288: 100.00
+	Hs
		1031769 B2CL2_HUMAN (6-231): 3.69e-51: 166: 39.38		BIK_HUMAN (1-160): 3.76e-101: 288: 100.00
+	Hs
		3078 A0A0S2Z3D2_HUMAN (1-126): 4.58e-47: 154: 99.21		BIK_HUMAN (1-160): 3.76e-101: 288: 100.00
+	Hs
		1031735 B2LA1_HUMAN (76-197): 1.25e-37: 131: 23.44		BIK_HUMAN (1-160): 3.76e-101: 288: 100.00
+	Hs
		992160 MCL1_HUMAN (36-195): 4.35e-36: 131: 25.00		BIK_HUMAN (1-160): 3.76e-101: 288: 100.00
+	Hs
		1031797 B2L10_HUMAN (77-221): 3.18e-33: 120: 18.79		BIK_HUMAN (1-160): 3.76e-101: 288: 100.00