HitPredict

Interactor 1: B2CL1 (Q07817)
Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)
Gene: BCL2L1

Interactor 2: APR (Q13794)
Phorbol-12-myristate-13-acetate-induced protein 1 (PMA-induced protein 1) (Immediate-early-response protein APR) (Protein Noxa)
Gene: PMAIP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.78 1.00 0.885

The method score is based on:

Property Details
Experiments 15721256, 15694340, 10807576, 21454712
Identification Methods unspecified method, affinity chromatography technology, surface plasmon resonance, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Bcl-2~PMAIP1
Common GO terms GO:0001836 - release of cytochrome c from mitochondria
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005829 - cytosol
GO:0046902 - regulation of mitochondrial membrane permeability
and 2 others

more...
Homologous interactions 7

Homologous interactions

Color coding for hit scores

1 233
Hs

1 54
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024