HitPredict

Interactor 1: PPARA (Q07869)
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene: PPARA

Interactor 2: NCOA2 (Q15596)
Nuclear receptor coactivator 2 (NCoA-2) (Class E basic helix-loop-helix protein 75) (bHLHe75) (Transcriptional intermediary factor 2) (hTIF2)
Gene: NCOA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.60 1.00 0.778

The method score is based on:

Property Details
Experiments 15888456, 21775429
Identification Methods pull down, amplified luminescent proximity homogeneous assay
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 3 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 468
Hs

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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024