HitPredict

Interactor 1: PPARA (Q07869)
Peroxisome proliferator-activated receptor alpha (PPAR-alpha) (Nuclear receptor subfamily 1 group C member 1)
Gene: PPARA

Interactor 2: NCOA3 (Q9Y6Q9)
Nuclear receptor coactivator 3 (NCoA-3) (EC 2.3.1.48) (ACTR) (Amplified in breast cancer 1 protein) (AIB-1) (CBP-interacting protein) (pCIP) (Class E basic helix-loop-helix protein 42) (bHLHe42) (Receptor-associated coactivator 3) (RAC-3) (Steroid receptor coactivator protein 3) (SRC-3) (Thyroid hormone receptor activator molecule 1) (TRAM-1)
Gene: NCOA3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	15888456
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	DUF4927~Hormone_recep, Hormone_recep~SRC-1
Common GO terms	GO:0000785 - chromatin GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 468 Hs			1 1424
+	Hs
		587212 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		500511 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		740635 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		874407 NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93		NCOA3_HUMAN (1-1424): 3.11e-164: 533: 100.00
+	Hs
		992420 PPARA_HUMAN (1-468): 1.4e-141: 415: 100.00		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		587195 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NPAS2_HUMAN (19-807): 7.51e-111: 372: 16.20
+	Hs
		587173 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		126103 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		BMAL1_HUMAN (6-541): 4.9e-105: 349: 18.23
+	Hs
		500487 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		992422 PPARA_HUMAN (1-468): 1.4e-141: 415: 100.00		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		740529 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Mm
		740717 PPARG_MOUSE (1-468): 7.9e-112: 341: 53.94		NCOA2_MOUSE (1-1422): 1.73e-98: 349: 38.93
+	Hs
		975430 PPARD_HUMAN (61-468): 1.11e-110: 336: 66.02		NCOA2_HUMAN (1-1422): 5.82e-99: 350: 38.89
+	Hs
		181498 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		CLOCK_HUMAN (1-791): 2.47e-78: 279: 13.73
+	Hs
		587177 RXRA_HUMAN (2-465): 5.7e-118: 355: 21.61		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		500491 THB_HUMAN (99-466): 3.59e-114: 345: 27.42		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		740535 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		874384 NR1H2_HUMAN (19-464): 4.66e-112: 340: 22.93		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		975432 PPARD_HUMAN (61-468): 1.11e-110: 336: 66.02		NCOA1_HUMAN (1-1353): 9.13e-76: 279: 24.53
+	Hs
		740556 PPARG_HUMAN (1-468): 2.71e-112: 342: 54.36		KMT2C_HUMAN (471-1383): 2.87e-11: 70.9: 12.87