Protein: GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (G gamma-I)

Gene: GBG2, GNG2
Organism: Homo sapiens
Interactions: 65
UniProt ID: P59768

Gene Ontology (top 5):
GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0007191 - adenylate cyclase-activating dopamine receptor signaling pathway
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

948051

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

15

20

Small-scale

0.763

High

948055

RACK1
Small ribosomal subunit protein RACK1

2

12

Small-scale

0.754

High

597349

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

8

20

Small-scale

0.750

High

948052

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

8

20

Small-scale

0.745

High

163627

GNB5
Guanine nucleotide-binding protein subunit beta-5

5

20

Small-scale

0.713

High

948081

GBB4
Guanine nucleotide-binding protein subunit beta-4

5

20

Small-scale

0.713

High

948079

WDR26
WD repeat-containing protein 26

1

11

Small-scale

0.662

High

948054

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

2

20

Small-scale

0.619

High

948070

WDFY1
WD repeat and FYVE domain-containing protein 1

1

1

High-throughput

0.618

High

948062

GNA13
Guanine nucleotide-binding protein subunit alpha-13

2

20

Small-scale

0.611

High

948089

NUFP1
FMR1-interacting protein NUFIP1

3

1

High-throughput

0.609

High

948053

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

2

20

Small-scale

0.584

High

948063

KCTD2
BTB/POZ domain-containing protein KCTD2

2

12

Small-scale

0.558

High

948073

KCD17
BTB/POZ domain-containing protein KCTD17

2

10

Small-scale

0.558

High

948085

KCTD5
BTB/POZ domain-containing protein KCTD5

2

12

Small-scale

0.558

High

71308

F1712
Protein FAM171A2

1

1

High-throughput

0.536

High

138818

STK25
Serine/threonine-protein kinase 25

1

1

High-throughput

0.536

High

318082

PKHG5
Pleckstrin homology domain-containing family G member 5

1

2

High-throughput

0.536

High

482595

GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

1

20

High-throughput

0.536

High

618449

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

20

High-throughput

0.536

High

716006

GNA11
Guanine nucleotide-binding protein subunit alpha-11

1

20

High-throughput

0.536

High

893472

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

20

High-throughput

0.536

High

948057

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

20

High-throughput

0.536

High

948064

RHEB
GTP-binding protein Rheb

1

1

High-throughput

0.536

High

948074

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.536

High

948086

STK26
Serine/threonine-protein kinase 26

1

1

High-throughput

0.536

High

948072

RPTOR
Regulatory-associated protein of mTOR

1

0

Small-scale

0.517

High

948056

ANK2
Ankyrin-2

1

0

High-throughput

0.513

High

948071

DCP1B
mRNA-decapping enzyme 1B

1

0

High-throughput

0.513

High

948082

MOG1
Ran guanine nucleotide release factor

1

0

High-throughput

0.513

High

948090

TBC24
TBC1 domain family member 24

1

0

High-throughput

0.513

High

948080

PKHG2
Pleckstrin homology domain-containing family G member 2

1

1

Small-scale

0.512

High

458356

ADRB2
Beta-2 adrenergic receptor

1

2

Small-scale

0.501

High

477188

ADA2A
Alpha-2A adrenergic receptor

1

2

Small-scale

0.501

High

640500

TA2R
Thromboxane A2 receptor

1

2

Small-scale

0.501

High

719772

V2R
Vasopressin V2 receptor

1

2

Small-scale

0.501

High

948076

MRGX1
Mas-related G-protein coupled receptor member X1

1

3

Small-scale

0.501

High

948060

PHLP
Phosducin-like protein

1

11

High-throughput

0.489

High

948067

KCD16
BTB/POZ domain-containing protein KCTD16

1

12

High-throughput

0.489

High

948068

TTBK2
Tau-tubulin kinase 2

1

2

High-throughput

0.489

High

948075

KCD12
BTB/POZ domain-containing protein KCTD12

1

12

High-throughput

0.489

High

948078

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

2

High-throughput

0.489

High

948059

ADCY2
Adenylate cyclase type 2

1

0

Small-scale

0.480

High

418632

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

20

Small-scale

0.479

High

440469

FYN
Tyrosine-protein kinase Fyn

1

3

Small-scale

0.479

High

948050

CD81
CD81 antigen

1

4

Small-scale

0.479

High

948058

FAK1
Focal adhesion kinase 1

1

4

Small-scale

0.479

High

948069

RICTR
Rapamycin-insensitive companion of mTOR

1

1

Small-scale

0.479

High

633902

ATP4A
Potassium-transporting ATPase alpha chain 1

1

0

Small-scale

0.458

High

723657

CALCR
Calcitonin receptor

1

0

Small-scale

0.458

High

839217

MTOR
Serine/threonine-protein kinase mTOR

1

0

Small-scale

0.458

High

882422

ARRB1
Beta-arrestin-1

1

0

Small-scale

0.458

High

948087

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

0

Small-scale

0.458

High

529452

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

371599

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

948088

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

948061

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

948077

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

337636

GNAS3
Neuroendocrine secretory protein 55

1

8

High-throughput

0.407

High

124291

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.347

High

948065

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.347

High

948083

KTU
Protein kintoun

3

0

High-throughput

0.347

High

948084

ARMC1
Armadillo repeat-containing protein 1

3

0

High-throughput

0.347

High

948066

BOREA
Borealin

2

0

High-throughput

0.318

High

948091

RRP7A
Ribosomal RNA-processing protein 7 homolog A

2

0

High-throughput

0.318

High


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Last updated: 11Aug2025