HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: EPS8 (Q12929)
Epidermal growth factor receptor kinase substrate 8
Gene: EPS8

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	1.00	0.873

Property	Details
Experiments	14565974, 27629044, 10499589, 16520382
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 822
+	Mm
		995945 SOS1_MOUSE (1-1333): 0: 957: 96.47		EPS8_MOUSE (1-822): 0: 956: 89.05
+	Hs
		992495 SOS1_HUMAN (1-1333): 0: 991: 100.00		ES8L2_HUMAN (7-811): 0: 769: 40.67
+	Hs
		992486 SOS1_HUMAN (1-1333): 0: 991: 100.00		ES8L1_HUMAN (29-805): 0: 717: 35.60
+	Hs
		802826 SOS1_HUMAN (1-1333): 0: 991: 100.00		CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79
+	Hs
		412150 SOS1_HUMAN (1-1333): 0: 991: 100.00		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		802575 SOS1_HUMAN (1-1333): 0: 991: 100.00		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Hs
		103875 G5E9C8_HUMAN (1-1333): 0: 972: 98.28		CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79
+	Mm
		815092 SOS1_MOUSE (1-1333): 0: 957: 96.47		CRKL_MOUSE (487-662): 4.53e-32: 128: 19.10
+	Hs
		557668 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Rn
		88907 D4A3T0_RAT (1-1333): 0: 958: 96.40		PACN1_RAT (435-586): 2.5e-27: 118: 17.53
+	Hs
		209038 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK2_HUMAN (535-612): 1.02e-12: 72.7: 24.69
+	Hs
		802827 SOS2_HUMAN (1-1332): 0: 855: 68.03		CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79
+	Hs
		412151 SOS2_HUMAN (1-1332): 0: 855: 68.03		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		802576 SOS2_HUMAN (1-1332): 0: 855: 68.03		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Hs
		557669 SOS2_HUMAN (1-1332): 0: 855: 68.03		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23
+	Dm
		644374 SOS_DROME (8-1305): 0: 692: 42.34		SRC42_DROME (501-594): 1.89e-14: 78.8: 23.23
+	Hs
		802840 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		CRKL_HUMAN (487-662): 3.07e-33: 132: 20.79
+	Hs
		412185 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		FYN_HUMAN (454-613): 1.08e-27: 120: 16.57
+	Hs
		802594 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		CRK_HUMAN (487-661): 8.43e-28: 116: 18.75
+	Hs
		557683 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		NCK1_HUMAN (536-621): 1.03e-18: 90.8: 30.23