Protein: RS21
Small ribosomal subunit protein eS21 (40S ribosomal protein S21)

Gene: RS21, RPS21
Organism: Homo sapiens
Interactions: 183
UniProt ID: P63220

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000461 - endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

476639

RSSA
Small ribosomal subunit protein uS2

12

15

Small-scale

0.979

High

586636

RS2
Small ribosomal subunit protein uS5

4

3

High-throughput

0.873

High

840677

RS27
Small ribosomal subunit protein eS27

4

3

High-throughput

0.676

High

371710

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.633

High

992476

CUL3
Cullin-3

2

1

High-throughput

0.611

High

992533

PKHF2
Pleckstrin homology domain-containing family F member 2

2

1

High-throughput

0.606

High

446881

NPM
Nucleophosmin

2

0

High-throughput

0.602

High

992477

BYST
Bystin

2

2

High-throughput

0.601

High

47510

RPSA2
Small ribosomal subunit protein uS2B

1

15

High-throughput

0.575

High

395866

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

858620

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

1

High-throughput

0.571

High

992474

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

1

High-throughput

0.571

High

992491

LARP7
La-related protein 7

2

0

High-throughput

0.559

High

992519

LRCH3
DISP complex protein LRCH3

2

0

High-throughput

0.559

High

249744

DOK2
Docking protein 2

2

0

High-throughput

0.547

High

619719

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.547

High

992485

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

161806

RIOK3
Serine/threonine-protein kinase RIO3

1

5

High-throughput

0.536

High

245214

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

2

High-throughput

0.536

High

687208

HMGB2
High mobility group protein B2

1

3

High-throughput

0.536

High

809582

RS19
Small ribosomal subunit protein eS19

1

4

High-throughput

0.536

High

859219

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.536

High

897001

MAP2
Methionine aminopeptidase 2

1

1

High-throughput

0.536

High

908941

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

939299

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

1

High-throughput

0.536

High

969782

RS16
Small ribosomal subunit protein uS9

1

2

High-throughput

0.536

High

992464

RACK1
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.536

High

992465

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.536

High

992473

G3BP1
Ras GTPase-activating protein-binding protein 1

1

6

High-throughput

0.536

High

992475

CUL1
Cullin-1

1

1

High-throughput

0.536

High

992490

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.536

High

992524

DNJC2
DnaJ homolog subfamily C member 2

1

2

High-throughput

0.536

High

992527

RBM42
RNA-binding protein 42

1

1

High-throughput

0.536

High

992549

G3BP2
Ras GTPase-activating protein-binding protein 2

1

5

High-throughput

0.536

High

992550

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

992551

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

2

High-throughput

0.536

High

271498

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

303512

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.513

High

362237

ABL1
Tyrosine-protein kinase ABL1

1

0

High-throughput

0.513

High

479396

SRP19
Signal recognition particle 19 kDa protein

1

0

High-throughput

0.513

High

542446

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

581509

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

0

High-throughput

0.513

High

785082

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

884056

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

886428

CTCF
Transcriptional repressor CTCF

1

0

High-throughput

0.513

High

900267

FXR2
RNA-binding protein FXR2

1

0

High-throughput

0.513

High

933305

IF5
Eukaryotic translation initiation factor 5

1

0

High-throughput

0.513

High

951090

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.513

High

985601

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

992471

TP53B
TP53-binding protein 1

1

0

High-throughput

0.513

High

992472

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.513

High

992480

CAPR1
Caprin-1

1

0

High-throughput

0.513

High

992481

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

992502

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

992510

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

992513

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

992546

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

977189

RS4X
Small ribosomal subunit protein eS4, X isoform

1

2

Small-scale

0.501

High

992499

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.481

High

992515

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

1

High-throughput

0.481

High

421891

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

955043

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

134668

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.479

High

238485

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

241349

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

315430

RECQ4
ATP-dependent DNA helicase Q4

1

3

High-throughput

0.479

High

319649

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

335084

ARI2
E3 ubiquitin-protein ligase ARIH2

1

2

High-throughput

0.479

High

406032

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

519927

ANDR
Androgen receptor

1

2

Small-scale

0.479

High

543163

UBL4A
Ubiquitin-like protein 4A

1

2

High-throughput

0.479

High

684188

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

693670

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

730497

1433S
14-3-3 protein sigma

1

1

Small-scale

0.479

High

786526

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

High-throughput

0.479

High

832013

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

2

High-throughput

0.479

High

860140

RS9
Small ribosomal subunit protein uS4

1

4

High-throughput

0.479

High

871919

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

1

High-throughput

0.479

High

973132

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.479

High

973387

RS11
Small ribosomal subunit protein uS17

1

3

High-throughput

0.479

High

983117

RS26
Small ribosomal subunit protein eS26

1

3

High-throughput

0.479

High

992467

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.479

High

992468

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

992469

TLE2
Transducin-like enhancer protein 2

1

1

High-throughput

0.479

High

992483

SYK
Lysine--tRNA ligase

1

1

High-throughput

0.479

High

992484

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

992487

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

992488

CCDC6
Coiled-coil domain-containing protein 6

1

1

High-throughput

0.479

High

992492

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.479

High

992494

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

992505

THOC2
THO complex subunit 2

1

1

High-throughput

0.479

High

992508

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

1

High-throughput

0.479

High

992511

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

992512

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

992514

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

992516

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

992529

TRI31
E3 ubiquitin-protein ligase TRIM31

1

1

High-throughput

0.479

High

992532

ECT2
Protein ECT2

1

1

High-throughput

0.479

High

992534

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

992535

ENY2
Transcription and mRNA export factor ENY2

1

1

High-throughput

0.479

High

992543

LYAR
Cell growth-regulating nucleolar protein

1

1

High-throughput

0.479

High

992548

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

992539

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

128950

MEN1
Menin

1

0

High-throughput

0.458

High

131932

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

142928

NFIB
Nuclear factor 1 B-type

1

0

High-throughput

0.458

High

157217

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

258101

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

286184

CSDE1
Cold shock domain-containing protein E1

1

0

High-throughput

0.458

High

293533

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

298347

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

302806

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.458

High

317561

SLIT2
Slit homolog 2 protein

1

0

High-throughput

0.458

High

324759

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

367579

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.458

High

418058

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

472617

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

480763

LEG1
Galectin-1

1

0

Small-scale

0.458

High

606598

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

667750

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

695173

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

720457

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.458

High

767928

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

830532

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

867027

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

872180

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

885743

KC1E
Casein kinase I isoform epsilon

1

0

High-throughput

0.458

High

937701

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

947154

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

956135

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.458

High

957311

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

970291

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

992466

H31
Histone H3.1

1

0

High-throughput

0.458

High

992470

AKP13
A-kinase anchor protein 13

1

0

High-throughput

0.458

High

992478

ELOA1
Elongin-A

1

0

High-throughput

0.458

High

992479

SRC8
Src substrate cortactin

1

0

High-throughput

0.458

High

992482

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

992486

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

992489

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

992493

SPOUT
28S rRNA

1

0

High-throughput

0.458

High

992496

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

992497

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

992498

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

992500

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

992501

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

992503

PHF6
PHD finger protein 6

1

0

High-throughput

0.458

High

992504

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

992506

RIN3
Ras and Rab interactor 3

1

0

High-throughput

0.458

High

992509

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

992517

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

992518

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

992520

THOC3
THO complex subunit 3

1

0

Small-scale

0.458

High

992522

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

992523

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

992536

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.458

High

992537

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

992538

ANLN
Anillin

1

0

High-throughput

0.458

High

992542

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

992544

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

992545

TES
Testin

1

0

High-throughput

0.458

High

992547

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

992554

RBM8A
RNA-binding protein 8A

1

0

High-throughput

0.458

High

992525

RIOK1
Serine/threonine-protein kinase RIO1

1

5

High-throughput

0.445

High

318717

RHBT1
Rho-related BTB domain-containing protein 1

1

1

High-throughput

0.437

High

400626

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.426

High

529581

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

563593

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

992530

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

992531

MAGT1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1

1

0

High-throughput

0.426

High

248206

NDK8
Putative nucleoside diphosphate kinase

1

1

High-throughput

0.407

High

783695

ZNF76
Zinc finger protein 76

2

0

High-throughput

0.316

High

992495

FHL5
Four and a half LIM domains protein 5

2

0

High-throughput

0.316

High

992528

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.305

High

377523

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

389262

FINC
Fibronectin

1

0

High-throughput

0.249

Low

565329

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

992507

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

992521

S41A2
Solute carrier family 41 member 2

1

0

High-throughput

0.249

Low

992526

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

992541

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.249

Low

992552

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

992553

MAFB
Transcription factor MafB

1

0

High-throughput

0.249

Low

992540

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025