HitPredict

Interactor 1: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	32203420, 14679214
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9, RhoGEF~SH3_1, RhoGEF~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0017124 - SH3 domain binding GO:0048011 - neurotrophin TRK receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1333 Hs			1 639
+	Hs
		992489 SOS1_HUMAN (1-1333): 0: 991: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		992527 SOS2_HUMAN (1-1332): 0: 855: 68.03		CD2AP_HUMAN (1-639): 9.29e-139: 420: 100.00
+	Hs
		209038 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Hs
		924511 SOS1_HUMAN (1-1333): 0: 991: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141134 SOS1_MOUSE (1-1333): 0: 957: 96.47		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		557668 SOS1_HUMAN (1-1333): 0: 991: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		992496 SOS1_HUMAN (1-1333): 0: 991: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		992477 SOS1_HUMAN (1-1333): 0: 991: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		275188 SOS2_HUMAN (1-1332): 0: 855: 68.03		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Hs
		924512 SOS2_HUMAN (1-1332): 0: 855: 68.03		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		970654 SOS2_MOUSE (1-1332): 0: 851: 67.66		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		557669 SOS2_HUMAN (1-1332): 0: 855: 68.03		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		992521 SOS2_HUMAN (1-1332): 0: 855: 68.03		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Hs
		992508 SOS2_HUMAN (1-1332): 0: 855: 68.03		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		924558 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1141157 Q91ZZ2_MOUSE (593-1032): 1.46e-88: 314: 24.21		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		557683 RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		1078876 PREX1_HUMAN (194-567): 2.78e-94: 337: 21.98		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Hs
		156402 RGRF2_HUMAN (360-991): 7.8e-85: 305: 17.89		DNMBP_HUMAN (113-602): 4.85e-17: 87.7: 15.23
+	Hs
		557756 RPGF5_HUMAN (522-1018): 7.32e-85: 291: 16.12		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24