HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: HECW1 (Q76N89)
E3 ubiquitin-protein ligase HECW1 (EC 2.3.2.26) (HECT, C2 and WW domain-containing protein 1) (HECT-type E3 ubiquitin transferase HECW1) (NEDD4-like E3 ubiquitin-protein ligase 1) (hNEDL1)
Gene: HECW1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	19144635
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 1606
+	Hs
		808104 ACK1_HUMAN (1-1038): 0: 805: 100.00		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		992607 ACK1_HUMAN (1-1038): 0: 805: 100.00		SMUF1_HUMAN (1034-1606): 0: 611: 33.82
+	Hs
		1070998 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		337392 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		262241 ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		412307 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		ITCH_HUMAN (865-1606): 0: 695: 30.78
+	Hs
		808314 ERRFI_HUMAN (445-889): 3.2e-139: 427: 30.21		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		808132 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		789045 ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		433282 YES_HUMAN (1-400): 1.3e-128: 403: 29.93		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		522850 SRC_HUMAN (1-400): 3.99e-127: 399: 31.42		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		412081 FYN_HUMAN (1-400): 2.52e-126: 397: 30.18		NEDD4_HUMAN (307-1604): 0: 656: 21.43
+	Hs
		125405 ACK1_HUMAN (1-1038): 0: 805: 100.00		WWP2_HUMAN (630-993): 7.45e-23: 108: 17.32
+	Mm
		222826 ACK1_MOUSE (1-1038): 0: 793: 92.70		NEDD4_MOUSE (754-1107): 6.29e-24: 111: 17.94
+	Hs
		992601 ACK1_HUMAN (1-1038): 0: 805: 100.00		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Hs
		337535 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Hs
		262307 ULK1_HUMAN (113-957): 7.3e-139: 446: 19.95		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96
+	Hs
		337496 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		HUWE1_HUMAN (443-917): 1.91e-09: 65.1: 9.71
+	Hs
		1071010 ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17		WWP1_HUMAN (599-984): 4.59e-19: 96: 16.58
+	Hs
		789085 ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68		NED4L_HUMAN (687-1062): 2.52e-15: 84.1: 15.96