HitPredict

Interactor 1: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Interactor 2: SOCS4 (Q8WXH5)
Suppressor of cytokine signaling 4 (SOCS-4) (Suppressor of cytokine signaling 7) (SOCS-7)
Gene: SOCS4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.80	0.686

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1038 Hs			1 440
+	Hs
		433331 ACK1_HUMAN (1-1038): 0: 805: 100.00		YES_HUMAN (151-429): 7.43e-47: 171: 14.19
+	Hs
		522936 ACK1_HUMAN (1-1038): 0: 805: 100.00		SRC_HUMAN (135-389): 2.54e-45: 166: 12.55
+	Hs
		412152 ACK1_HUMAN (1-1038): 0: 805: 100.00		FYN_HUMAN (202-387): 3.13e-42: 158: 17.10
+	Hs
		442817 ACK1_HUMAN (1-1038): 0: 805: 100.00		HCK_HUMAN (157-430): 3.66e-42: 158: 15.49
+	Hs
		782781 ACK1_HUMAN (1-1038): 0: 805: 100.00		CSK_HUMAN (244-379): 2.34e-33: 132: 18.98
+	Hs
		992597 ACK1_HUMAN (1-1038): 0: 805: 100.00		P55G_HUMAN (282-394): 1.03e-16: 84.1: 21.74
+	Hs
		655334 ACK1_HUMAN (1-1038): 0: 805: 100.00		P85A_HUMAN (225-392): 2.48e-15: 80.3: 18.71
+	Hs
		337491 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SHE_HUMAN (165-384): 5.1e-48: 173: 12.61
+	Mm
		337630 ABL1_MOUSE (1-955): 1.72e-152: 484: 20.27		CISH_MOUSE (211-425): 1.16e-40: 147: 23.32
+	Hs
		337329 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SRC_HUMAN (135-389): 2.54e-45: 166: 12.55
+	Hs
		181753 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SOCS1_HUMAN (260-425): 6.95e-46: 159: 22.29
+	Hs
		337307 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		FYN_HUMAN (202-387): 3.13e-42: 158: 17.10
+	Hs
		337315 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		HCK_HUMAN (157-430): 3.66e-42: 158: 15.49
+	Hs
		147369 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		SOCS3_HUMAN (250-422): 2.34e-37: 137: 20.09
+	Dm
		993220 ACK_DROME (4-1030): 1.31e-167: 522: 30.15		GRAP_DROME (273-378): 2.34e-13: 70.6: 22.43
+	Mm
		1208603 ERRFI_MOUSE (445-889): 1.36e-151: 460: 30.69		PLCG2_MOUSE (258-399): 1.84e-23: 105: 16.78
+	Hs
		337341 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		PLCG1_HUMAN (261-379): 1.1e-22: 103: 17.50
+	Hs
		129151 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		P85B_HUMAN (231-382): 5.27e-18: 88.7: 20.65
+	Hs
		337356 ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03		P85A_HUMAN (225-392): 2.48e-15: 80.3: 18.71
+	Hs
		69198 A9UF07_HUMAN (1-955): 2.36e-134: 447: 19.03		P85B_HUMAN (231-382): 5.27e-18: 88.7: 20.65