Protein: IF5A1
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)

Gene: IF5A1, EIF5A
Organism: Homo sapiens
Interactions: 212
UniProt ID: P63241

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003746 - translation elongation factor activity
GO:0005634 - nucleus
GO:0005642 - annulate lamellae
GO:0005643 - nuclear pore

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

881763

DHYS
Deoxyhypusine synthase

3

7

High-throughput

0.871

High

992646

IF5A2
Eukaryotic translation initiation factor 5A-2

2

3

High-throughput

0.789

High

992597

IF5AL
Eukaryotic translation initiation factor 5A-1-like

2

3

High-throughput

0.754

High

241350

PRKN
E3 ubiquitin-protein ligase parkin

4

3

High-throughput

0.686

High

992567

REL
Proto-oncogene c-Rel

3

1

High-throughput

0.675

High

992639

DOHH
Deoxyhypusine hydroxylase

3

2

High-throughput

0.667

High

893810

MEOX2
Homeobox protein MOX-2

2

1

High-throughput

0.633

High

324760

HEXI1
Protein HEXIM1

2

2

High-throughput

0.611

High

140221

SDCB1
Syntenin-1

2

1

High-throughput

0.606

High

192366

GSC2
Homeobox protein goosecoid-2

2

2

High-throughput

0.606

High

916120

LBX1
Transcription factor LBX1

2

1

High-throughput

0.606

High

395867

ESR1
Estrogen receptor

2

1

Small-scale

0.595

High

375383

RASK
GTPase KRas

1

0

High-throughput

0.586

High

992568

KPCZ
Protein kinase C zeta type

2

0

High-throughput

0.585

High

934434

TERA
Transitional endoplasmic reticulum ATPase

2

3

High-throughput

0.584

High

992658

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

992575

CUL3
Cullin-3

2

4

High-throughput

0.571

High

992638

SH3G3
Endophilin-A3

2

2

High-throughput

0.571

High

992667

GAB2
GRB2-associated-binding protein 2

2

2

High-throughput

0.571

High

536932

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.559

High

978464

RL23A
Large ribosomal subunit protein uL23

2

0

Small-scale

0.559

High

992564

RT15
Small ribosomal subunit protein uS15m

2

0

High-throughput

0.559

High

992641

ACE2
Angiotensin-converting enzyme 2

2

0

Small-scale

0.559

High

859220

RL5
Large ribosomal subunit protein uL18

1

0

Small-scale

0.549

High

209978

CRX
Cone-rod homeobox protein

1

0

High-throughput

0.549

High

992665

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.536

High

583525

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

607570

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

2

High-throughput

0.536

High

659203

SP100
Nuclear autoantigen Sp-100

1

3

High-throughput

0.536

High

683985

PTN3
Tyrosine-protein phosphatase non-receptor type 3

1

1

High-throughput

0.536

High

691698

MK03
Mitogen-activated protein kinase 3

1

1

High-throughput

0.536

High

783552

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

908883

NEK3
Serine/threonine-protein kinase Nek3

1

3

High-throughput

0.536

High

992565

CDK6
Cyclin-dependent kinase 6

1

2

High-throughput

0.536

High

992574

CUL2
Cullin-2

1

4

High-throughput

0.536

High

992586

MYLK
Myosin light chain kinase, smooth muscle

1

2

High-throughput

0.536

High

992588

DUS7
Dual specificity protein phosphatase 7

1

4

High-throughput

0.536

High

992607

MYLK4
Myosin light chain kinase family member 4

1

1

High-throughput

0.536

High

992618

MK15
Mitogen-activated protein kinase 15

1

3

High-throughput

0.536

High

992620

NEK7
Serine/threonine-protein kinase Nek7

1

2

High-throughput

0.536

High

992629

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

992656

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.536

High

992596

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

135585

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

163918

NDC80
Kinetochore protein NDC80 homolog

1

0

High-throughput

0.513

High

213889

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

251560

CCNT1
Cyclin-T1

1

0

High-throughput

0.513

High

361215

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

563594

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

773856

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

787972

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

992580

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

992583

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

992593

TENS2
Tensin-2

1

0

High-throughput

0.513

High

992602

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.513

High

992609

RBM45
RNA-binding protein 45

1

0

High-throughput

0.513

High

992614

RETR2
Reticulophagy regulator 2

1

0

High-throughput

0.513

High

992617

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

992642

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

992650

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.513

High

992668

TDRKH
Tudor and KH domain-containing protein

1

0

High-throughput

0.513

High

992647

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.508

High

964205

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

992561

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.501

High

992645

XPO4
Exportin-4

1

1

Small-scale

0.501

High

166643

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

1

High-throughput

0.489

High

172682

XPO1
Exportin-1

1

0

Small-scale

0.480

High

992659

SENP1
Sentrin-specific protease 1

1

0

Small-scale

0.480

High

48284

E2F8
Transcription factor E2F8

1

1

High-throughput

0.479

High

259766

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

341551

EYA4
Protein phosphatase EYA4

1

3

High-throughput

0.479

High

371711

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.479

High

476640

RSSA
Small ribosomal subunit protein uS2

1

1

High-throughput

0.479

High

587442

TFE2
Transcription factor E2-alpha

1

1

High-throughput

0.479

High

606599

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

629761

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

655145

SFPQ
Splicing factor, proline- and glutamine-rich

1

2

High-throughput

0.479

High

685495

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

687209

HMGB2
High mobility group protein B2

1

3

High-throughput

0.479

High

791275

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

809583

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.479

High

822593

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.479

High

933612

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.479

High

954086

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

957312

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

959722

RS3A
Small ribosomal subunit protein eS1

1

2

High-throughput

0.479

High

970292

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

978844

RS6
Small ribosomal subunit protein eS6

1

1

Small-scale

0.479

High

985119

RL10A
Large ribosomal subunit protein uL1

1

1

Small-scale

0.479

High

992566

EWS
RNA-binding protein EWS

1

3

High-throughput

0.479

High

992569

DUSP2
Dual specificity protein phosphatase 2

1

4

High-throughput

0.479

High

992570

EMAL5
Echinoderm microtubule-associated protein-like 5

1

2

High-throughput

0.479

High

992573

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

1

High-throughput

0.479

High

992576

SRC8
Src substrate cortactin

1

2

High-throughput

0.479

High

992578

CUL7
Cullin-7

1

2

High-throughput

0.479

High

992581

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

992582

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

992584

PDIA6
Protein disulfide-isomerase A6

1

3

High-throughput

0.479

High

992585

NONO
Non-POU domain-containing octamer-binding protein

1

2

High-throughput

0.479

High

992587

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.479

High

992589

CCD57
Coiled-coil domain-containing protein 57

1

2

High-throughput

0.479

High

992591

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

992594

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.479

High

992600

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

992604

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

992610

SMC5
Structural maintenance of chromosomes protein 5

1

2

High-throughput

0.479

High

992612

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.479

High

992619

BICD2
Protein bicaudal D homolog 2

1

2

High-throughput

0.479

High

992622

DUS19
Dual specificity protein phosphatase 19

1

5

High-throughput

0.479

High

992623

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

1

High-throughput

0.479

High

992625

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.479

High

992626

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

992627

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

992631

OPTN
Optineurin

1

2

High-throughput

0.479

High

992634

CI072
Guanine nucleotide exchange factor C9orf72

1

1

High-throughput

0.479

High

992640

DUS26
Dual specificity protein phosphatase 26

1

4

High-throughput

0.479

High

992657

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

992663

DS13B
Dual specificity protein phosphatase 13B

1

4

High-throughput

0.479

High

992664

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

992666

DUS12
Dual specificity protein phosphatase 12

1

4

High-throughput

0.479

High

125398

LEG9
Galectin-9

1

0

High-throughput

0.458

High

212204

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

228229

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

280572

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.458

High

293534

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

315431

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

319650

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

338101

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.458

High

345647

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

359632

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

385636

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

408799

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

446882

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

462861

LAMB1
Laminin subunit beta-1

1

0

High-throughput

0.458

High

487179

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

541936

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.458

High

556000

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

588436

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

642792

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.458

High

674991

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

675452

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

695174

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

718798

CCND2
G1/S-specific cyclin-D2

1

0

Small-scale

0.458

High

736465

NAC1
Sodium/calcium exchanger 1

1

0

High-throughput

0.458

High

766429

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

772139

MSX2
Homeobox protein MSX-2

1

0

High-throughput

0.458

High

878934

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

884308

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

887947

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

889071

RBM25
RNA-binding protein 25

1

0

High-throughput

0.458

High

937702

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

947155

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

964828

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

992562

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

992563

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.458

High

992571

SRSF9
Serine/arginine-rich splicing factor 9

1

0

High-throughput

0.458

High

992572

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

992579

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

992590

FA76B
Protein FAM76B

1

0

High-throughput

0.458

High

992592

DDI2
Protein DDI1 homolog 2

1

0

High-throughput

0.458

High

992595

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

992598

FIP1
Pre-mRNA 3'-end-processing factor FIP1

1

0

High-throughput

0.458

High

992601

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

992603

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

992606

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

992608

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

992613

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

992615

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

992621

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

992624

ATX2L
Ataxin-2-like protein

1

0

High-throughput

0.458

High

992630

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

992632

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

992635

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.458

High

992636

NECD
Necdin

1

0

High-throughput

0.458

High

992637

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

992644

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

992648

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.458

High

992653

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

992655

ZN532
Zinc finger protein 532

1

0

High-throughput

0.458

High

992660

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

992661

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

992662

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.458

High

992670

SPIN1
Spindlin-1

1

0

High-throughput

0.458

High

327929

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

4

High-throughput

0.445

High

429695

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

587046

ITF2
Transcription factor 4

1

1

High-throughput

0.445

High

765358

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

943902

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

992628

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.445

High

992649

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

4

High-throughput

0.445

High

992651

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

4

High-throughput

0.445

High

353232

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

992599

WDR82
WD repeat-containing protein 82

1

3

High-throughput

0.437

High

992652

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

404763

PRIO
Major prion protein

1

0

High-throughput

0.426

High

529582

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

635851

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

992611

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

992643

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

71509

MEI4
Meiosis-specific protein MEI4

2

0

High-throughput

0.316

High

992605

ST32C
Serine/threonine-protein kinase 32C

1

0

High-throughput

0.279

Low

992616

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

1007

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.253

Low

105726

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

239806

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

720458

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.249

Low

767929

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

992577

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

992633

DYH8
Dynein axonemal heavy chain 8

1

0

High-throughput

0.249

Low

992654

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.249

Low

992669

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

653242

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025